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Relationship between thyroid stimulating hormone and night shift work

BACKGROUND: Night shift work has well-known adverse effects on health. However, few studies have investigated the relationship between thyroid diseases and night shift work. This study aimed to examine night shift workers and their changes in thyroid stimulating hormones (TSH) levels over time. METH...

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Autores principales: Moon, So-Hyun, Lee, Bum-Joon, Kim, Seong-Jin, Kim, Hwan-Cheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054581/
https://www.ncbi.nlm.nih.gov/pubmed/27761265
http://dx.doi.org/10.1186/s40557-016-0141-0
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author Moon, So-Hyun
Lee, Bum-Joon
Kim, Seong-Jin
Kim, Hwan-Cheol
author_facet Moon, So-Hyun
Lee, Bum-Joon
Kim, Seong-Jin
Kim, Hwan-Cheol
author_sort Moon, So-Hyun
collection PubMed
description BACKGROUND: Night shift work has well-known adverse effects on health. However, few studies have investigated the relationship between thyroid diseases and night shift work. This study aimed to examine night shift workers and their changes in thyroid stimulating hormones (TSH) levels over time. METHODS: Medical check-up data (2011–2015) were obtained from 967 female workers at a university hospital in Incheon, Korea. Data regarding TSH levels were extracted from the records, and 2015 was used as a reference point to determine night shift work status. The relationships between TSH levels and night shift work in each year were analyzed using the general linear model (GLM). The generalized estimating equation (GEE) was used to evaluate the repeated measurements over the 5-year period. RESULTS: The GEE analysis revealed that from 2011 to 2015, night shift workers had TSH levels that were 0.303 mIU/L higher than the levels of non-night shift workers (95 % CI: 0.087–0.519 mIU/L, p = 0.006) after adjusting for age and department. When we used TSH levels of 4.5 ≥ mIU/L to identify subclinical hypothyroidism, night shift workers exhibited a 1.399 fold higher risk of subclinical hypothyroidism (95 % CI: 1.050–1.863, p = 0.022), compared to their non-night shift counterparts. CONCLUSIONS: This result of this study suggests that night shift workers may have an increased risk of thyroid diseases, compared to non-night shift workers.
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spelling pubmed-50545812016-10-19 Relationship between thyroid stimulating hormone and night shift work Moon, So-Hyun Lee, Bum-Joon Kim, Seong-Jin Kim, Hwan-Cheol Ann Occup Environ Med Research Article BACKGROUND: Night shift work has well-known adverse effects on health. However, few studies have investigated the relationship between thyroid diseases and night shift work. This study aimed to examine night shift workers and their changes in thyroid stimulating hormones (TSH) levels over time. METHODS: Medical check-up data (2011–2015) were obtained from 967 female workers at a university hospital in Incheon, Korea. Data regarding TSH levels were extracted from the records, and 2015 was used as a reference point to determine night shift work status. The relationships between TSH levels and night shift work in each year were analyzed using the general linear model (GLM). The generalized estimating equation (GEE) was used to evaluate the repeated measurements over the 5-year period. RESULTS: The GEE analysis revealed that from 2011 to 2015, night shift workers had TSH levels that were 0.303 mIU/L higher than the levels of non-night shift workers (95 % CI: 0.087–0.519 mIU/L, p = 0.006) after adjusting for age and department. When we used TSH levels of 4.5 ≥ mIU/L to identify subclinical hypothyroidism, night shift workers exhibited a 1.399 fold higher risk of subclinical hypothyroidism (95 % CI: 1.050–1.863, p = 0.022), compared to their non-night shift counterparts. CONCLUSIONS: This result of this study suggests that night shift workers may have an increased risk of thyroid diseases, compared to non-night shift workers. BioMed Central 2016-10-06 /pmc/articles/PMC5054581/ /pubmed/27761265 http://dx.doi.org/10.1186/s40557-016-0141-0 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Moon, So-Hyun
Lee, Bum-Joon
Kim, Seong-Jin
Kim, Hwan-Cheol
Relationship between thyroid stimulating hormone and night shift work
title Relationship between thyroid stimulating hormone and night shift work
title_full Relationship between thyroid stimulating hormone and night shift work
title_fullStr Relationship between thyroid stimulating hormone and night shift work
title_full_unstemmed Relationship between thyroid stimulating hormone and night shift work
title_short Relationship between thyroid stimulating hormone and night shift work
title_sort relationship between thyroid stimulating hormone and night shift work
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054581/
https://www.ncbi.nlm.nih.gov/pubmed/27761265
http://dx.doi.org/10.1186/s40557-016-0141-0
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