Cargando…
Utility of susceptibility-weighted imaging in Parkinson’s disease and atypical Parkinsonian disorders
In the clinic, the diagnosis of Parkinson’s disease (PD) largely depends on clinicians’ experience. When the diagnosis is made, approximately 80% of dopaminergic cells in the substantia nigra (SN) have been lost. Additionally, it is rather challenging to differentiate PD from atypical parkinsonian d...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054585/ https://www.ncbi.nlm.nih.gov/pubmed/27761236 http://dx.doi.org/10.1186/s40035-016-0064-2 |
_version_ | 1782458628493541376 |
---|---|
author | Wang, Zhibin Luo, Xiao-Guang Gao, Chao |
author_facet | Wang, Zhibin Luo, Xiao-Guang Gao, Chao |
author_sort | Wang, Zhibin |
collection | PubMed |
description | In the clinic, the diagnosis of Parkinson’s disease (PD) largely depends on clinicians’ experience. When the diagnosis is made, approximately 80% of dopaminergic cells in the substantia nigra (SN) have been lost. Additionally, it is rather challenging to differentiate PD from atypical parkinsonian disorders (APD). Clinially-available 3T conventional MRI contributes little to solve these problems. The pathologic alterations of parkinsonism show abnormal brain iron deposition, and therefore susceptibility-weighted imaging (SWI), which is sensitive to iron concentration, has been applied to find iron-related lesions for the diagnosis and differentiation of PD in recent decades. Until now, the majority of research has revealed that in SWI the signal intensity changes in deep brain nuclei, such as the SN, the putamen (PUT), the globus pallidus (GP), the thalamus (TH), the red nucleus (RN) and the caudate nucleus (CN), thereby raising the possibility of early diagnosis and differentiation. Furthermore, the signal changes in SN, PUT and TH sub-regions may settle the issues with higher accuracy. In this article, we review the brain iron deposition of PD, MSA-P and PSP in SWI in the hope of exhibiting a profile of SWI features in PD, MSA and PSP and its clinical values. |
format | Online Article Text |
id | pubmed-5054585 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-50545852016-10-19 Utility of susceptibility-weighted imaging in Parkinson’s disease and atypical Parkinsonian disorders Wang, Zhibin Luo, Xiao-Guang Gao, Chao Transl Neurodegener Review In the clinic, the diagnosis of Parkinson’s disease (PD) largely depends on clinicians’ experience. When the diagnosis is made, approximately 80% of dopaminergic cells in the substantia nigra (SN) have been lost. Additionally, it is rather challenging to differentiate PD from atypical parkinsonian disorders (APD). Clinially-available 3T conventional MRI contributes little to solve these problems. The pathologic alterations of parkinsonism show abnormal brain iron deposition, and therefore susceptibility-weighted imaging (SWI), which is sensitive to iron concentration, has been applied to find iron-related lesions for the diagnosis and differentiation of PD in recent decades. Until now, the majority of research has revealed that in SWI the signal intensity changes in deep brain nuclei, such as the SN, the putamen (PUT), the globus pallidus (GP), the thalamus (TH), the red nucleus (RN) and the caudate nucleus (CN), thereby raising the possibility of early diagnosis and differentiation. Furthermore, the signal changes in SN, PUT and TH sub-regions may settle the issues with higher accuracy. In this article, we review the brain iron deposition of PD, MSA-P and PSP in SWI in the hope of exhibiting a profile of SWI features in PD, MSA and PSP and its clinical values. BioMed Central 2016-10-07 /pmc/articles/PMC5054585/ /pubmed/27761236 http://dx.doi.org/10.1186/s40035-016-0064-2 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Wang, Zhibin Luo, Xiao-Guang Gao, Chao Utility of susceptibility-weighted imaging in Parkinson’s disease and atypical Parkinsonian disorders |
title | Utility of susceptibility-weighted imaging in Parkinson’s disease and atypical Parkinsonian disorders |
title_full | Utility of susceptibility-weighted imaging in Parkinson’s disease and atypical Parkinsonian disorders |
title_fullStr | Utility of susceptibility-weighted imaging in Parkinson’s disease and atypical Parkinsonian disorders |
title_full_unstemmed | Utility of susceptibility-weighted imaging in Parkinson’s disease and atypical Parkinsonian disorders |
title_short | Utility of susceptibility-weighted imaging in Parkinson’s disease and atypical Parkinsonian disorders |
title_sort | utility of susceptibility-weighted imaging in parkinson’s disease and atypical parkinsonian disorders |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054585/ https://www.ncbi.nlm.nih.gov/pubmed/27761236 http://dx.doi.org/10.1186/s40035-016-0064-2 |
work_keys_str_mv | AT wangzhibin utilityofsusceptibilityweightedimaginginparkinsonsdiseaseandatypicalparkinsoniandisorders AT luoxiaoguang utilityofsusceptibilityweightedimaginginparkinsonsdiseaseandatypicalparkinsoniandisorders AT gaochao utilityofsusceptibilityweightedimaginginparkinsonsdiseaseandatypicalparkinsoniandisorders |