IMPACT is a GCN2 inhibitor that limits lifespan in Caenorhabditis elegans

BACKGROUND: The General Control Nonderepressible 2 (GCN2) kinase is a conserved member of the integrated stress response (ISR) pathway that represses protein translation and helps cells to adapt to conditions of nutrient shortage. As such, GCN2 is required for longevity and stress resistance induced...

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Detalles Bibliográficos
Autores principales: Ferraz, Rafael C., Camara, Henrique, De-Souza, Evandro A., Pinto, Silas, Pinca, Ana Paula F., Silva, Richard C., Sato, Vitor N., Castilho, Beatriz A., Mori, Marcelo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054600/
https://www.ncbi.nlm.nih.gov/pubmed/27717342
http://dx.doi.org/10.1186/s12915-016-0301-2

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