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Relationship between negative symptoms and neurocognitive functions in adolescent and adult patients with first-episode schizophrenia

BACKGROUND: This study aimed to explore differences in links between negative symptoms and neurocognitive deficits in adolescent and adult patients with first-episode schizophrenia. Schizophrenia is a mental disorder often characterized by positive and negative symptoms, reduced emotional expression...

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Autores principales: Huang, Manli, Huang, Yi, Yu, Liang, Hu, Jianbo, Chen, Jinkai, Jin, Pingbo, Xu, Weijuan, Wei, Ning, Hu, Shaohua, Qi, Hongli, Xu, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054618/
https://www.ncbi.nlm.nih.gov/pubmed/27716115
http://dx.doi.org/10.1186/s12888-016-1052-x
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author Huang, Manli
Huang, Yi
Yu, Liang
Hu, Jianbo
Chen, Jinkai
Jin, Pingbo
Xu, Weijuan
Wei, Ning
Hu, Shaohua
Qi, Hongli
Xu, Yi
author_facet Huang, Manli
Huang, Yi
Yu, Liang
Hu, Jianbo
Chen, Jinkai
Jin, Pingbo
Xu, Weijuan
Wei, Ning
Hu, Shaohua
Qi, Hongli
Xu, Yi
author_sort Huang, Manli
collection PubMed
description BACKGROUND: This study aimed to explore differences in links between negative symptoms and neurocognitive deficits in adolescent and adult patients with first-episode schizophrenia. Schizophrenia is a mental disorder often characterized by positive and negative symptoms, reduced emotional expression, excitatory status, and poor cognitive ability. The severity of negative symptoms in patients with schizophrenia was reported to be more related to poor quality of life, weak functional ability, and heavy burden from families than with the severity of positive symptoms. Previous studies suggested correlations between the severity of negative symptoms in patients with schizophrenia and neurocognitive deficits. METHODS: This study included 92 patients (33 adolescents and 59 adults) with first-episode schizophrenia and 57 healthy people matched by age and education level. Neurocognitive functions and clinical symptoms were assessed using a standardized questionnaire. RESULTS: Patients with first-episode schizophrenia showed neurocognitive deficits in most neuropsychological assessments compared with healthy people. With the variable of education level controlled, the negative factor score of adolescent patients with first-episode schizophrenia was strongly correlated with more time spent in part 1 (r = .646) and part 2 (r = .663) of the trail making test, and moderately correlated to more perseverative errors (r = .425) of the Wisconsin card sorting test and fewer correct trials 2 (r = −.425) of the continuous performance test. However, no such correlations were found in adult patients. CONCLUSIONS: This study indicated significant correlations between negative symptoms and most neurocognitive functions in patients with first-episode schizophrenia, with a stronger correlation in adolescent patients. TRIAL REGISTRATION: The trial registration number is ChiCTR-COC-14005302, while retrospectively registered on January 5, 2014.
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spelling pubmed-50546182016-10-19 Relationship between negative symptoms and neurocognitive functions in adolescent and adult patients with first-episode schizophrenia Huang, Manli Huang, Yi Yu, Liang Hu, Jianbo Chen, Jinkai Jin, Pingbo Xu, Weijuan Wei, Ning Hu, Shaohua Qi, Hongli Xu, Yi BMC Psychiatry Research Article BACKGROUND: This study aimed to explore differences in links between negative symptoms and neurocognitive deficits in adolescent and adult patients with first-episode schizophrenia. Schizophrenia is a mental disorder often characterized by positive and negative symptoms, reduced emotional expression, excitatory status, and poor cognitive ability. The severity of negative symptoms in patients with schizophrenia was reported to be more related to poor quality of life, weak functional ability, and heavy burden from families than with the severity of positive symptoms. Previous studies suggested correlations between the severity of negative symptoms in patients with schizophrenia and neurocognitive deficits. METHODS: This study included 92 patients (33 adolescents and 59 adults) with first-episode schizophrenia and 57 healthy people matched by age and education level. Neurocognitive functions and clinical symptoms were assessed using a standardized questionnaire. RESULTS: Patients with first-episode schizophrenia showed neurocognitive deficits in most neuropsychological assessments compared with healthy people. With the variable of education level controlled, the negative factor score of adolescent patients with first-episode schizophrenia was strongly correlated with more time spent in part 1 (r = .646) and part 2 (r = .663) of the trail making test, and moderately correlated to more perseverative errors (r = .425) of the Wisconsin card sorting test and fewer correct trials 2 (r = −.425) of the continuous performance test. However, no such correlations were found in adult patients. CONCLUSIONS: This study indicated significant correlations between negative symptoms and most neurocognitive functions in patients with first-episode schizophrenia, with a stronger correlation in adolescent patients. TRIAL REGISTRATION: The trial registration number is ChiCTR-COC-14005302, while retrospectively registered on January 5, 2014. BioMed Central 2016-10-06 /pmc/articles/PMC5054618/ /pubmed/27716115 http://dx.doi.org/10.1186/s12888-016-1052-x Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Huang, Manli
Huang, Yi
Yu, Liang
Hu, Jianbo
Chen, Jinkai
Jin, Pingbo
Xu, Weijuan
Wei, Ning
Hu, Shaohua
Qi, Hongli
Xu, Yi
Relationship between negative symptoms and neurocognitive functions in adolescent and adult patients with first-episode schizophrenia
title Relationship between negative symptoms and neurocognitive functions in adolescent and adult patients with first-episode schizophrenia
title_full Relationship between negative symptoms and neurocognitive functions in adolescent and adult patients with first-episode schizophrenia
title_fullStr Relationship between negative symptoms and neurocognitive functions in adolescent and adult patients with first-episode schizophrenia
title_full_unstemmed Relationship between negative symptoms and neurocognitive functions in adolescent and adult patients with first-episode schizophrenia
title_short Relationship between negative symptoms and neurocognitive functions in adolescent and adult patients with first-episode schizophrenia
title_sort relationship between negative symptoms and neurocognitive functions in adolescent and adult patients with first-episode schizophrenia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054618/
https://www.ncbi.nlm.nih.gov/pubmed/27716115
http://dx.doi.org/10.1186/s12888-016-1052-x
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