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The Role of IRE-XBP1 Pathway in Regulation of Retinal Pigment Epithelium Tight Junctions

PURPOSE: The retinal pigment epithelium (RPE) tight junctions play a pivotal role in maintaining the homeostatic environment of the neural retina. Herein, we investigated the role of X-box binding protein 1 (XBP1), an endoplasmic reticulum (ER) stress-responsive transcription factor, in regulation o...

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Detalles Bibliográficos
Autores principales: Ma, Jacey H., Wang, Joshua J., Li, Junhua, Pfeffer, Bruce A., Zhong, Yiming, Zhang, Sarah X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054729/
https://www.ncbi.nlm.nih.gov/pubmed/27701635
http://dx.doi.org/10.1167/iovs.16-19232