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A limit to the divergent allele advantage model supported by variable pathogen recognition across HLA‐DRB1 allele lineages
Genetic diversity in human leukocyte antigen (HLA) molecules is thought to have arisen from the co‐evolution between host and pathogen and maintained by balancing selection. Heterozygote advantage is a common proposed scenario for maintaining high levels of diversity in HLA genes, and extending from...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Blackwell Publishing Ltd
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054888/ https://www.ncbi.nlm.nih.gov/pubmed/26392055 http://dx.doi.org/10.1111/tan.12667 |