Somatic mutations and affinity maturation are impaired by excessive numbers of T follicular helper cells and restored by Treg cells or memory T cells

We previously reported that Cd3e‐deficient mice adoptively transferred with CD4(+) T cells generate high numbers of T follicular helper (Tfh) cells, which go on to induce a strong B‐cell and germinal center (GC) reaction. Here, we show that in this system, GC B cells display an altered distribution...

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Detalles Bibliográficos
Autores principales: Preite, Silvia, Baumjohann, Dirk, Foglierini, Mathilde, Basso, Camilla, Ronchi, Francesca, Rodriguez, Blanca M. Fernandez, Corti, Davide, Lanzavecchia, Antonio, Sallusto, Federica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
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Highlights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054911/
https://www.ncbi.nlm.nih.gov/pubmed/26332258
http://dx.doi.org/10.1002/eji.201545920

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