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The Evolution of Aggregative Multicellularity and Cell–Cell Communication in the Dictyostelia

Aggregative multicellularity, resulting in formation of a spore-bearing fruiting body, evolved at least six times independently amongst both eukaryotes and prokaryotes. Amongst eukaryotes, this form of multicellularity is mainly studied in the social amoeba Dictyostelium discoideum. In this review,...

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Autores principales: Du, Qingyou, Kawabe, Yoshinori, Schilde, Christina, Chen, Zhi-hui, Schaap, Pauline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055082/
https://www.ncbi.nlm.nih.gov/pubmed/26284972
http://dx.doi.org/10.1016/j.jmb.2015.08.008
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author Du, Qingyou
Kawabe, Yoshinori
Schilde, Christina
Chen, Zhi-hui
Schaap, Pauline
author_facet Du, Qingyou
Kawabe, Yoshinori
Schilde, Christina
Chen, Zhi-hui
Schaap, Pauline
author_sort Du, Qingyou
collection PubMed
description Aggregative multicellularity, resulting in formation of a spore-bearing fruiting body, evolved at least six times independently amongst both eukaryotes and prokaryotes. Amongst eukaryotes, this form of multicellularity is mainly studied in the social amoeba Dictyostelium discoideum. In this review, we summarise trends in the evolution of cell-type specialisation and behavioural complexity in the four major groups of Dictyostelia. We describe the cell–cell communication systems that control the developmental programme of D. discoideum, highlighting the central role of cAMP in the regulation of cell movement and cell differentiation. Comparative genomic studies showed that the proteins involved in cAMP signalling are deeply conserved across Dictyostelia and their unicellular amoebozoan ancestors. Comparative functional analysis revealed that cAMP signalling in D. discoideum originated from a second messenger role in amoebozoan encystation. We highlight some molecular changes in cAMP signalling genes that were responsible for the novel roles of cAMP in multicellular development.
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spelling pubmed-50550822016-10-12 The Evolution of Aggregative Multicellularity and Cell–Cell Communication in the Dictyostelia Du, Qingyou Kawabe, Yoshinori Schilde, Christina Chen, Zhi-hui Schaap, Pauline J Mol Biol Article Aggregative multicellularity, resulting in formation of a spore-bearing fruiting body, evolved at least six times independently amongst both eukaryotes and prokaryotes. Amongst eukaryotes, this form of multicellularity is mainly studied in the social amoeba Dictyostelium discoideum. In this review, we summarise trends in the evolution of cell-type specialisation and behavioural complexity in the four major groups of Dictyostelia. We describe the cell–cell communication systems that control the developmental programme of D. discoideum, highlighting the central role of cAMP in the regulation of cell movement and cell differentiation. Comparative genomic studies showed that the proteins involved in cAMP signalling are deeply conserved across Dictyostelia and their unicellular amoebozoan ancestors. Comparative functional analysis revealed that cAMP signalling in D. discoideum originated from a second messenger role in amoebozoan encystation. We highlight some molecular changes in cAMP signalling genes that were responsible for the novel roles of cAMP in multicellular development. Elsevier 2015-11-20 /pmc/articles/PMC5055082/ /pubmed/26284972 http://dx.doi.org/10.1016/j.jmb.2015.08.008 Text en © 2015 The Authors. Published by Elsevier Ltd. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Du, Qingyou
Kawabe, Yoshinori
Schilde, Christina
Chen, Zhi-hui
Schaap, Pauline
The Evolution of Aggregative Multicellularity and Cell–Cell Communication in the Dictyostelia
title The Evolution of Aggregative Multicellularity and Cell–Cell Communication in the Dictyostelia
title_full The Evolution of Aggregative Multicellularity and Cell–Cell Communication in the Dictyostelia
title_fullStr The Evolution of Aggregative Multicellularity and Cell–Cell Communication in the Dictyostelia
title_full_unstemmed The Evolution of Aggregative Multicellularity and Cell–Cell Communication in the Dictyostelia
title_short The Evolution of Aggregative Multicellularity and Cell–Cell Communication in the Dictyostelia
title_sort evolution of aggregative multicellularity and cell–cell communication in the dictyostelia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055082/
https://www.ncbi.nlm.nih.gov/pubmed/26284972
http://dx.doi.org/10.1016/j.jmb.2015.08.008
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