Cargando…
The Evolution of Aggregative Multicellularity and Cell–Cell Communication in the Dictyostelia
Aggregative multicellularity, resulting in formation of a spore-bearing fruiting body, evolved at least six times independently amongst both eukaryotes and prokaryotes. Amongst eukaryotes, this form of multicellularity is mainly studied in the social amoeba Dictyostelium discoideum. In this review,...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055082/ https://www.ncbi.nlm.nih.gov/pubmed/26284972 http://dx.doi.org/10.1016/j.jmb.2015.08.008 |
_version_ | 1782458716763717632 |
---|---|
author | Du, Qingyou Kawabe, Yoshinori Schilde, Christina Chen, Zhi-hui Schaap, Pauline |
author_facet | Du, Qingyou Kawabe, Yoshinori Schilde, Christina Chen, Zhi-hui Schaap, Pauline |
author_sort | Du, Qingyou |
collection | PubMed |
description | Aggregative multicellularity, resulting in formation of a spore-bearing fruiting body, evolved at least six times independently amongst both eukaryotes and prokaryotes. Amongst eukaryotes, this form of multicellularity is mainly studied in the social amoeba Dictyostelium discoideum. In this review, we summarise trends in the evolution of cell-type specialisation and behavioural complexity in the four major groups of Dictyostelia. We describe the cell–cell communication systems that control the developmental programme of D. discoideum, highlighting the central role of cAMP in the regulation of cell movement and cell differentiation. Comparative genomic studies showed that the proteins involved in cAMP signalling are deeply conserved across Dictyostelia and their unicellular amoebozoan ancestors. Comparative functional analysis revealed that cAMP signalling in D. discoideum originated from a second messenger role in amoebozoan encystation. We highlight some molecular changes in cAMP signalling genes that were responsible for the novel roles of cAMP in multicellular development. |
format | Online Article Text |
id | pubmed-5055082 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-50550822016-10-12 The Evolution of Aggregative Multicellularity and Cell–Cell Communication in the Dictyostelia Du, Qingyou Kawabe, Yoshinori Schilde, Christina Chen, Zhi-hui Schaap, Pauline J Mol Biol Article Aggregative multicellularity, resulting in formation of a spore-bearing fruiting body, evolved at least six times independently amongst both eukaryotes and prokaryotes. Amongst eukaryotes, this form of multicellularity is mainly studied in the social amoeba Dictyostelium discoideum. In this review, we summarise trends in the evolution of cell-type specialisation and behavioural complexity in the four major groups of Dictyostelia. We describe the cell–cell communication systems that control the developmental programme of D. discoideum, highlighting the central role of cAMP in the regulation of cell movement and cell differentiation. Comparative genomic studies showed that the proteins involved in cAMP signalling are deeply conserved across Dictyostelia and their unicellular amoebozoan ancestors. Comparative functional analysis revealed that cAMP signalling in D. discoideum originated from a second messenger role in amoebozoan encystation. We highlight some molecular changes in cAMP signalling genes that were responsible for the novel roles of cAMP in multicellular development. Elsevier 2015-11-20 /pmc/articles/PMC5055082/ /pubmed/26284972 http://dx.doi.org/10.1016/j.jmb.2015.08.008 Text en © 2015 The Authors. Published by Elsevier Ltd. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Du, Qingyou Kawabe, Yoshinori Schilde, Christina Chen, Zhi-hui Schaap, Pauline The Evolution of Aggregative Multicellularity and Cell–Cell Communication in the Dictyostelia |
title | The Evolution of Aggregative Multicellularity and Cell–Cell Communication in the Dictyostelia |
title_full | The Evolution of Aggregative Multicellularity and Cell–Cell Communication in the Dictyostelia |
title_fullStr | The Evolution of Aggregative Multicellularity and Cell–Cell Communication in the Dictyostelia |
title_full_unstemmed | The Evolution of Aggregative Multicellularity and Cell–Cell Communication in the Dictyostelia |
title_short | The Evolution of Aggregative Multicellularity and Cell–Cell Communication in the Dictyostelia |
title_sort | evolution of aggregative multicellularity and cell–cell communication in the dictyostelia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055082/ https://www.ncbi.nlm.nih.gov/pubmed/26284972 http://dx.doi.org/10.1016/j.jmb.2015.08.008 |
work_keys_str_mv | AT duqingyou theevolutionofaggregativemulticellularityandcellcellcommunicationinthedictyostelia AT kawabeyoshinori theevolutionofaggregativemulticellularityandcellcellcommunicationinthedictyostelia AT schildechristina theevolutionofaggregativemulticellularityandcellcellcommunicationinthedictyostelia AT chenzhihui theevolutionofaggregativemulticellularityandcellcellcommunicationinthedictyostelia AT schaappauline theevolutionofaggregativemulticellularityandcellcellcommunicationinthedictyostelia AT duqingyou evolutionofaggregativemulticellularityandcellcellcommunicationinthedictyostelia AT kawabeyoshinori evolutionofaggregativemulticellularityandcellcellcommunicationinthedictyostelia AT schildechristina evolutionofaggregativemulticellularityandcellcellcommunicationinthedictyostelia AT chenzhihui evolutionofaggregativemulticellularityandcellcellcommunicationinthedictyostelia AT schaappauline evolutionofaggregativemulticellularityandcellcellcommunicationinthedictyostelia |