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Clinicopathological feature and prognosis of primary hepatic gastrointestinal stromal tumor

Compared to gastric gastrointestinal stromal tumor (GIST), hepatic GIST is very rare in clinic. Reports on clinicopathological feature and prognosis of this rare disease are limited in literature. The purpose of this study was, therefore, to summarize clinical and pathological features as well as pr...

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Autores principales: Liu, Zhen, Tian, Yangzi, Liu, Shushang, Xu, Guanghui, Guo, Man, Lian, Xiao, Fan, Daiming, Zhang, Hongwei, Feng, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055144/
https://www.ncbi.nlm.nih.gov/pubmed/27484851
http://dx.doi.org/10.1002/cam4.808
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author Liu, Zhen
Tian, Yangzi
Liu, Shushang
Xu, Guanghui
Guo, Man
Lian, Xiao
Fan, Daiming
Zhang, Hongwei
Feng, Fan
author_facet Liu, Zhen
Tian, Yangzi
Liu, Shushang
Xu, Guanghui
Guo, Man
Lian, Xiao
Fan, Daiming
Zhang, Hongwei
Feng, Fan
author_sort Liu, Zhen
collection PubMed
description Compared to gastric gastrointestinal stromal tumor (GIST), hepatic GIST is very rare in clinic. Reports on clinicopathological feature and prognosis of this rare disease are limited in literature. The purpose of this study was, therefore, to summarize clinical and pathological features as well as prognosis of the primary hepatic GIST. One case of primary hepatic GIST from our center and 22 cases reported in MEDLINE or China National Knowledge Infrastructure (CNKI) were enrolled into this study. Clinicopathological features as well as survival data of hepatic GIST were analyzed and compared with 297 gastric GISTs and 59 small intestinal GISTs from our center. Majority of the 22 cases (95.7%) of hepatic GIST was larger than 5 cm in size, and 75.0% of the tumors were over 5/50 HPF in mitotic index. Most of the hepatic GISTs (85.7%) displayed spindle cell shape in morphology. All of the hepatic GIST (100%) enrolled in this study were classified as high‐risk category by the National Institute of Health (NIH) risk classification. The 5‐year median disease‐free survival (DFS) time was 24.0 months and 5‐year disease‐specific survival (DSS) rate was 33.3%, respectively. Distribution of clinicopathological features was significantly different among hepatic, gastric, and small intestinal GIST. The DFS and DSS of hepatic GIST were significantly lower than those of the other two groups. Majority of the hepatic GIST is large in size and highly malignant. Prognosis of the primary hepatic GIST is worse than that of gastric GIST and small intestinal GIST.
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spelling pubmed-50551442016-12-12 Clinicopathological feature and prognosis of primary hepatic gastrointestinal stromal tumor Liu, Zhen Tian, Yangzi Liu, Shushang Xu, Guanghui Guo, Man Lian, Xiao Fan, Daiming Zhang, Hongwei Feng, Fan Cancer Med Clinical Cancer Research Compared to gastric gastrointestinal stromal tumor (GIST), hepatic GIST is very rare in clinic. Reports on clinicopathological feature and prognosis of this rare disease are limited in literature. The purpose of this study was, therefore, to summarize clinical and pathological features as well as prognosis of the primary hepatic GIST. One case of primary hepatic GIST from our center and 22 cases reported in MEDLINE or China National Knowledge Infrastructure (CNKI) were enrolled into this study. Clinicopathological features as well as survival data of hepatic GIST were analyzed and compared with 297 gastric GISTs and 59 small intestinal GISTs from our center. Majority of the 22 cases (95.7%) of hepatic GIST was larger than 5 cm in size, and 75.0% of the tumors were over 5/50 HPF in mitotic index. Most of the hepatic GISTs (85.7%) displayed spindle cell shape in morphology. All of the hepatic GIST (100%) enrolled in this study were classified as high‐risk category by the National Institute of Health (NIH) risk classification. The 5‐year median disease‐free survival (DFS) time was 24.0 months and 5‐year disease‐specific survival (DSS) rate was 33.3%, respectively. Distribution of clinicopathological features was significantly different among hepatic, gastric, and small intestinal GIST. The DFS and DSS of hepatic GIST were significantly lower than those of the other two groups. Majority of the hepatic GIST is large in size and highly malignant. Prognosis of the primary hepatic GIST is worse than that of gastric GIST and small intestinal GIST. John Wiley and Sons Inc. 2016-08-03 /pmc/articles/PMC5055144/ /pubmed/27484851 http://dx.doi.org/10.1002/cam4.808 Text en © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Cancer Research
Liu, Zhen
Tian, Yangzi
Liu, Shushang
Xu, Guanghui
Guo, Man
Lian, Xiao
Fan, Daiming
Zhang, Hongwei
Feng, Fan
Clinicopathological feature and prognosis of primary hepatic gastrointestinal stromal tumor
title Clinicopathological feature and prognosis of primary hepatic gastrointestinal stromal tumor
title_full Clinicopathological feature and prognosis of primary hepatic gastrointestinal stromal tumor
title_fullStr Clinicopathological feature and prognosis of primary hepatic gastrointestinal stromal tumor
title_full_unstemmed Clinicopathological feature and prognosis of primary hepatic gastrointestinal stromal tumor
title_short Clinicopathological feature and prognosis of primary hepatic gastrointestinal stromal tumor
title_sort clinicopathological feature and prognosis of primary hepatic gastrointestinal stromal tumor
topic Clinical Cancer Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055144/
https://www.ncbi.nlm.nih.gov/pubmed/27484851
http://dx.doi.org/10.1002/cam4.808
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