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Updated mortality study of a cohort of asbestos textile workers

Limited information is available on risk of peritoneal mesothelioma after asbestos exposure, and in general on the risk of cancer after cessation of asbestos exposure. We updated to 2013 the follow‐up of a cohort of 1083 female and 894 male textile workers with heavy asbestos exposure (up to 100 fb/...

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Autores principales: Pira, Enrico, Romano, Canzio, Violante, Francesco S., Farioli, Andrea, Spatari, Giovanna, La Vecchia, Carlo, Boffetta, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055168/
https://www.ncbi.nlm.nih.gov/pubmed/27457053
http://dx.doi.org/10.1002/cam4.824
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author Pira, Enrico
Romano, Canzio
Violante, Francesco S.
Farioli, Andrea
Spatari, Giovanna
La Vecchia, Carlo
Boffetta, Paolo
author_facet Pira, Enrico
Romano, Canzio
Violante, Francesco S.
Farioli, Andrea
Spatari, Giovanna
La Vecchia, Carlo
Boffetta, Paolo
author_sort Pira, Enrico
collection PubMed
description Limited information is available on risk of peritoneal mesothelioma after asbestos exposure, and in general on the risk of cancer after cessation of asbestos exposure. We updated to 2013 the follow‐up of a cohort of 1083 female and 894 male textile workers with heavy asbestos exposure (up to 100 fb/mL), often for short periods. A total of 1019 deaths were observed, corresponding to a standardized mortality ratio (SMR) of 1.68 (95% confidence interval [CI]: 1.57–1.78). SMRs were 29.1 (95% CI: 21.5–38.6) for peritoneal cancer, 2.96 (95% CI: 2.50–3.49) for lung cancer, 33.7 (95% CI: 25.7–43.4) for pleural cancer, and 3.03 (95% CI: 1.69–4.99) for ovarian cancer. For pleural and peritoneal cancer, there was no consistent pattern of risk in relation to time since last exposure, whereas for lung cancer there was an indication of a decline in risk after 25 years since last exposure. The findings of this unique cohort provide novel data for peritoneal cancer, indicating that – as for pleural cancer – the excess risk does not decline up to several decades after cessation of exposure.
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spelling pubmed-50551682016-12-12 Updated mortality study of a cohort of asbestos textile workers Pira, Enrico Romano, Canzio Violante, Francesco S. Farioli, Andrea Spatari, Giovanna La Vecchia, Carlo Boffetta, Paolo Cancer Med Cancer Prevention Limited information is available on risk of peritoneal mesothelioma after asbestos exposure, and in general on the risk of cancer after cessation of asbestos exposure. We updated to 2013 the follow‐up of a cohort of 1083 female and 894 male textile workers with heavy asbestos exposure (up to 100 fb/mL), often for short periods. A total of 1019 deaths were observed, corresponding to a standardized mortality ratio (SMR) of 1.68 (95% confidence interval [CI]: 1.57–1.78). SMRs were 29.1 (95% CI: 21.5–38.6) for peritoneal cancer, 2.96 (95% CI: 2.50–3.49) for lung cancer, 33.7 (95% CI: 25.7–43.4) for pleural cancer, and 3.03 (95% CI: 1.69–4.99) for ovarian cancer. For pleural and peritoneal cancer, there was no consistent pattern of risk in relation to time since last exposure, whereas for lung cancer there was an indication of a decline in risk after 25 years since last exposure. The findings of this unique cohort provide novel data for peritoneal cancer, indicating that – as for pleural cancer – the excess risk does not decline up to several decades after cessation of exposure. John Wiley and Sons Inc. 2016-07-25 /pmc/articles/PMC5055168/ /pubmed/27457053 http://dx.doi.org/10.1002/cam4.824 Text en © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Prevention
Pira, Enrico
Romano, Canzio
Violante, Francesco S.
Farioli, Andrea
Spatari, Giovanna
La Vecchia, Carlo
Boffetta, Paolo
Updated mortality study of a cohort of asbestos textile workers
title Updated mortality study of a cohort of asbestos textile workers
title_full Updated mortality study of a cohort of asbestos textile workers
title_fullStr Updated mortality study of a cohort of asbestos textile workers
title_full_unstemmed Updated mortality study of a cohort of asbestos textile workers
title_short Updated mortality study of a cohort of asbestos textile workers
title_sort updated mortality study of a cohort of asbestos textile workers
topic Cancer Prevention
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055168/
https://www.ncbi.nlm.nih.gov/pubmed/27457053
http://dx.doi.org/10.1002/cam4.824
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