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Impact of age on adjuvant chemotherapy after radical resection in patients with non–small cell lung cancer
Adjuvant chemotherapy (ACT) after radical surgery is known to improve the survival of patients with non–small cell lung cancer (NSCLC). However, there are few studies reporting the impact of age on the efficacy of ACT in NSCLC patients. All patients who received postoperative ACT in the Cancer Hospi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055170/ https://www.ncbi.nlm.nih.gov/pubmed/27367482 http://dx.doi.org/10.1002/cam4.814 |
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author | Zhai, Xiaoyu Yang, Lu Chen, Sipeng Zheng, Qiwen Wang, Ziping |
author_facet | Zhai, Xiaoyu Yang, Lu Chen, Sipeng Zheng, Qiwen Wang, Ziping |
author_sort | Zhai, Xiaoyu |
collection | PubMed |
description | Adjuvant chemotherapy (ACT) after radical surgery is known to improve the survival of patients with non–small cell lung cancer (NSCLC). However, there are few studies reporting the impact of age on the efficacy of ACT in NSCLC patients. All patients who received postoperative ACT in the Cancer Hospital, the Chinese Academy of Medical Sciences, between 2001 and 2013 with complete records in the database of the hospital and met the inclusion criteria were enrolled in this study for analysis. The primary end point was disease‐free survival (DFS) in terms of age. Survival analysis was performed using Kaplan–Meier estimates, log‐rank tests, and Cox's proportional hazards regression analysis. Propensity score matching (PSM) was used, survival analysis and subgroup analysis of the match data were carried out. Of 1095 patients with stage IB to stage IIIA NSCLC who underwent radical resection, 865 cases who met the inclusion criteria were analyzed. Of them, 156 (18.0%) patients were 65 years old or older, and the remaining 709 (82.0%) patients were younger than 65. The DFS between the younger group and the elderly group was not significantly different neither before PSM (100.714 weeks [95% CI: 84.421, 117.007] vs. 99.571 weeks [95% CI: 82.621, 116.522]; P = 0.555) nor after PSM (104.857 weeks [95% CI: 81.495, 128.220] vs. 97.429 weeks [95% CI: 81.743, 113.114]; P = 0.328) using the Kaplan–Meier method.The results suggest that the benefit on DFS was similar regardless of age of NSCLC patients. ACT should not be withheld from elderly patients. However, these conclusions are limited by the nature of this retrospective study, and therefore prospective trials are required for further verification. |
format | Online Article Text |
id | pubmed-5055170 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-50551702016-12-12 Impact of age on adjuvant chemotherapy after radical resection in patients with non–small cell lung cancer Zhai, Xiaoyu Yang, Lu Chen, Sipeng Zheng, Qiwen Wang, Ziping Cancer Med Clinical Cancer Research Adjuvant chemotherapy (ACT) after radical surgery is known to improve the survival of patients with non–small cell lung cancer (NSCLC). However, there are few studies reporting the impact of age on the efficacy of ACT in NSCLC patients. All patients who received postoperative ACT in the Cancer Hospital, the Chinese Academy of Medical Sciences, between 2001 and 2013 with complete records in the database of the hospital and met the inclusion criteria were enrolled in this study for analysis. The primary end point was disease‐free survival (DFS) in terms of age. Survival analysis was performed using Kaplan–Meier estimates, log‐rank tests, and Cox's proportional hazards regression analysis. Propensity score matching (PSM) was used, survival analysis and subgroup analysis of the match data were carried out. Of 1095 patients with stage IB to stage IIIA NSCLC who underwent radical resection, 865 cases who met the inclusion criteria were analyzed. Of them, 156 (18.0%) patients were 65 years old or older, and the remaining 709 (82.0%) patients were younger than 65. The DFS between the younger group and the elderly group was not significantly different neither before PSM (100.714 weeks [95% CI: 84.421, 117.007] vs. 99.571 weeks [95% CI: 82.621, 116.522]; P = 0.555) nor after PSM (104.857 weeks [95% CI: 81.495, 128.220] vs. 97.429 weeks [95% CI: 81.743, 113.114]; P = 0.328) using the Kaplan–Meier method.The results suggest that the benefit on DFS was similar regardless of age of NSCLC patients. ACT should not be withheld from elderly patients. However, these conclusions are limited by the nature of this retrospective study, and therefore prospective trials are required for further verification. John Wiley and Sons Inc. 2016-07-01 /pmc/articles/PMC5055170/ /pubmed/27367482 http://dx.doi.org/10.1002/cam4.814 Text en © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Cancer Research Zhai, Xiaoyu Yang, Lu Chen, Sipeng Zheng, Qiwen Wang, Ziping Impact of age on adjuvant chemotherapy after radical resection in patients with non–small cell lung cancer |
title | Impact of age on adjuvant chemotherapy after radical resection in patients with non–small cell lung cancer |
title_full | Impact of age on adjuvant chemotherapy after radical resection in patients with non–small cell lung cancer |
title_fullStr | Impact of age on adjuvant chemotherapy after radical resection in patients with non–small cell lung cancer |
title_full_unstemmed | Impact of age on adjuvant chemotherapy after radical resection in patients with non–small cell lung cancer |
title_short | Impact of age on adjuvant chemotherapy after radical resection in patients with non–small cell lung cancer |
title_sort | impact of age on adjuvant chemotherapy after radical resection in patients with non–small cell lung cancer |
topic | Clinical Cancer Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055170/ https://www.ncbi.nlm.nih.gov/pubmed/27367482 http://dx.doi.org/10.1002/cam4.814 |
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