Dual pharmacological inhibition of glutathione and thioredoxin systems synergizes to kill colorectal carcinoma stem cells

NRF2 stabilizes redox potential through genes for glutathione and thioredoxin antioxidant systems. Whether blockade of glutathione and thioredoxin is useful in eliminating cancer stem cells remain unknown. We used xenografts derived from colorectal carcinoma patients to investigate the pharmacologic...

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Detalles Bibliográficos
Autores principales: Tanaka, Genki, Inoue, Ken‐ichi, Shimizu, Takayuki, Akimoto, Kazumi, Kubota, Keiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055185/
https://www.ncbi.nlm.nih.gov/pubmed/27485632
http://dx.doi.org/10.1002/cam4.844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055185/
https://www.ncbi.nlm.nih.gov/pubmed/27485632
http://dx.doi.org/10.1002/cam4.844

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