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Combination of lentivirus-mediated silencing of PPM1D and temozolomide chemotherapy eradicates malignant glioma through cell apoptosis and cell cycle arrest

Temozolomide (TMZ) is approved for use as first-line treatment for glioblastoma multiforme (GBM). However, GBM shows chemoresistance shortly after the initiation of treatment. In order to detect whether silencing of human protein phosphatase 1D magnesium dependent (PPM1D) gene could increase the eff...

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Detalles Bibliográficos
Autores principales:	Wang, Peng, Ye, Jing-An, Hou, Chong-Xian, Zhou, Dong, Zhan, Sheng-Quan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055212/ https://www.ncbi.nlm.nih.gov/pubmed/27633132 http://dx.doi.org/10.3892/or.2016.5089

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