Omeprazole Alleviates Aristolochia manshuriensis Kom-Induced Acute Nephrotoxicity

Aristolochia manshuriensis Kom (AMK) is a member of the Aristolochiaceae family and is a well-known cause of aristolochic acid (AA) nephropathy. In this study, we investigated the potential of omeprazole (OM) to alleviate AMK-induced nephrotoxicity. We found that OM reduced mouse mortality caused by...

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Detalles Bibliográficos
Autores principales: Wang, Lianmei, Zhang, Hongbing, Li, Chunying, Yi, Yan, Liu, Jing, Zhao, Yong, Tian, Jingzhuo, Zhang, Yushi, Wei, Xiaolu, Gao, Yue, Liang, Aihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055352/
https://www.ncbi.nlm.nih.gov/pubmed/27716846
http://dx.doi.org/10.1371/journal.pone.0164215
Descripción
Sumario:Aristolochia manshuriensis Kom (AMK) is a member of the Aristolochiaceae family and is a well-known cause of aristolochic acid (AA) nephropathy. In this study, we investigated the potential of omeprazole (OM) to alleviate AMK-induced nephrotoxicity. We found that OM reduced mouse mortality caused by AMK and attenuated AMK-induced acute nephrotoxicity in rats. OM enhanced hepatic Cyp 1a1/2 and renal Cyp 1a1 expression in rats, as well as CYP 1A1 expression in human renal tubular epithelial cells (HKCs). HKCs with ectopic CYP 1A1 expression were more tolerant to AA than the control cells. Therefore, OM may alleviate AMK-mediated acute nephrotoxicity through induction of CYP 1A1. We suggest that the coadministration of OM might be beneficial for reducing of AA-induced nephrotoxicity.

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