The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer

Breast tumors often display extreme genetic heterogeneity characterized by hundreds of gross chromosomal aberrations and tens of thousands of somatic mutations. Tumor evolution is thought to be ongoing and driven by multiple mutagenic processes. A major outstanding question is whether primary tumors...

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Detalles Bibliográficos
Autores principales: Law, Emily K., Sieuwerts, Anieta M., LaPara, Kelly, Leonard, Brandon, Starrett, Gabriel J., Molan, Amy M., Temiz, Nuri A., Vogel, Rachel Isaksson, Meijer-van Gelder, Marion E., Sweep, Fred C. G. J., Span, Paul N., Foekens, John A., Martens, John W. M., Yee, Douglas, Harris, Reuben S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055383/
https://www.ncbi.nlm.nih.gov/pubmed/27730215
http://dx.doi.org/10.1126/sciadv.1601737

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