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Current status of diagnosis and treatment of hepatic echinococcosis

Echinococcus granulosus (E. granulosus) and Echinococcus multilocularis (E. multilocularis) infections are the most common parasitic diseases that affect the liver. The disease course is typically slow and the patients tend to remain asymptomatic for many years. Often the diagnosis is incidental. Ri...

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Autores principales: Mihmanli, Memmet, Idiz, Ufuk Oguz, Kaya, Cemal, Demir, Uygar, Bostanci, Ozgur, Omeroglu, Sinan, Bozkurt, Emre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055586/
https://www.ncbi.nlm.nih.gov/pubmed/27729953
http://dx.doi.org/10.4254/wjh.v8.i28.1169
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author Mihmanli, Memmet
Idiz, Ufuk Oguz
Kaya, Cemal
Demir, Uygar
Bostanci, Ozgur
Omeroglu, Sinan
Bozkurt, Emre
author_facet Mihmanli, Memmet
Idiz, Ufuk Oguz
Kaya, Cemal
Demir, Uygar
Bostanci, Ozgur
Omeroglu, Sinan
Bozkurt, Emre
author_sort Mihmanli, Memmet
collection PubMed
description Echinococcus granulosus (E. granulosus) and Echinococcus multilocularis (E. multilocularis) infections are the most common parasitic diseases that affect the liver. The disease course is typically slow and the patients tend to remain asymptomatic for many years. Often the diagnosis is incidental. Right upper quadrant abdominal pain, hepatitis, cholangitis, and anaphylaxis due to dissemination of the cyst are the main presenting symptoms. Ultrasonography is important in diagnosis. The World Health Organization classification, based on ultrasonographic findings, is used for staging of the disease and treatment selection. In addition to the imaging methods, immunological investigations are used to support the diagnosis. The available treatment options for E. granulosus infection include open surgery, percutaneous interventions, and pharmacotherapy. Aggressive surgery is the first-choice treatment for E. multilocularis infection, while pharmacotherapy is used as an adjunct to surgery. Due to a paucity of clinical studies, empirical evidence on the treatment of E. granulosus and E. multilocularis infections is largely lacking; there are no prominent and widely accepted clinical algorithms yet. In this article, we review the diagnosis and treatment of E. granulosus and E. multilocularis infections in the light of recent evidence.
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spelling pubmed-50555862016-10-11 Current status of diagnosis and treatment of hepatic echinococcosis Mihmanli, Memmet Idiz, Ufuk Oguz Kaya, Cemal Demir, Uygar Bostanci, Ozgur Omeroglu, Sinan Bozkurt, Emre World J Hepatol Review Echinococcus granulosus (E. granulosus) and Echinococcus multilocularis (E. multilocularis) infections are the most common parasitic diseases that affect the liver. The disease course is typically slow and the patients tend to remain asymptomatic for many years. Often the diagnosis is incidental. Right upper quadrant abdominal pain, hepatitis, cholangitis, and anaphylaxis due to dissemination of the cyst are the main presenting symptoms. Ultrasonography is important in diagnosis. The World Health Organization classification, based on ultrasonographic findings, is used for staging of the disease and treatment selection. In addition to the imaging methods, immunological investigations are used to support the diagnosis. The available treatment options for E. granulosus infection include open surgery, percutaneous interventions, and pharmacotherapy. Aggressive surgery is the first-choice treatment for E. multilocularis infection, while pharmacotherapy is used as an adjunct to surgery. Due to a paucity of clinical studies, empirical evidence on the treatment of E. granulosus and E. multilocularis infections is largely lacking; there are no prominent and widely accepted clinical algorithms yet. In this article, we review the diagnosis and treatment of E. granulosus and E. multilocularis infections in the light of recent evidence. Baishideng Publishing Group Inc 2016-10-08 2016-10-08 /pmc/articles/PMC5055586/ /pubmed/27729953 http://dx.doi.org/10.4254/wjh.v8.i28.1169 Text en ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Review
Mihmanli, Memmet
Idiz, Ufuk Oguz
Kaya, Cemal
Demir, Uygar
Bostanci, Ozgur
Omeroglu, Sinan
Bozkurt, Emre
Current status of diagnosis and treatment of hepatic echinococcosis
title Current status of diagnosis and treatment of hepatic echinococcosis
title_full Current status of diagnosis and treatment of hepatic echinococcosis
title_fullStr Current status of diagnosis and treatment of hepatic echinococcosis
title_full_unstemmed Current status of diagnosis and treatment of hepatic echinococcosis
title_short Current status of diagnosis and treatment of hepatic echinococcosis
title_sort current status of diagnosis and treatment of hepatic echinococcosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055586/
https://www.ncbi.nlm.nih.gov/pubmed/27729953
http://dx.doi.org/10.4254/wjh.v8.i28.1169
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