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Risk of selection bias in randomized trials: further insight
The quality of randomization is an under-appreciated facet of trial design. The present piece represents an advance in our collective understanding of how allocation concealment and randomization relate to risk of selection bias in randomized trials, and other measures are also considered. Though th...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055691/ https://www.ncbi.nlm.nih.gov/pubmed/27717392 http://dx.doi.org/10.1186/s13063-016-1597-5 |
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author | Berger, Vance W. |
author_facet | Berger, Vance W. |
author_sort | Berger, Vance W. |
collection | PubMed |
description | The quality of randomization is an under-appreciated facet of trial design. The present piece represents an advance in our collective understanding of how allocation concealment and randomization relate to risk of selection bias in randomized trials, and other measures are also considered. Though the overwhelming majority of the advice given is timely and correct, it is more instructive to focus on the relatively narrow sliver of advice that is incorrect (namely, that trials should not stratify by site, and that unrestricted randomization is a solution to the problem of selection bias), so it is in this context that the comments here must be understood. In no way is this intended to be a rebuttal of the excellent work we have before us. Rather, it is a refinement. |
format | Online Article Text |
id | pubmed-5055691 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-50556912016-10-19 Risk of selection bias in randomized trials: further insight Berger, Vance W. Trials Commentary The quality of randomization is an under-appreciated facet of trial design. The present piece represents an advance in our collective understanding of how allocation concealment and randomization relate to risk of selection bias in randomized trials, and other measures are also considered. Though the overwhelming majority of the advice given is timely and correct, it is more instructive to focus on the relatively narrow sliver of advice that is incorrect (namely, that trials should not stratify by site, and that unrestricted randomization is a solution to the problem of selection bias), so it is in this context that the comments here must be understood. In no way is this intended to be a rebuttal of the excellent work we have before us. Rather, it is a refinement. BioMed Central 2016-10-07 /pmc/articles/PMC5055691/ /pubmed/27717392 http://dx.doi.org/10.1186/s13063-016-1597-5 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Commentary Berger, Vance W. Risk of selection bias in randomized trials: further insight |
title | Risk of selection bias in randomized trials: further insight |
title_full | Risk of selection bias in randomized trials: further insight |
title_fullStr | Risk of selection bias in randomized trials: further insight |
title_full_unstemmed | Risk of selection bias in randomized trials: further insight |
title_short | Risk of selection bias in randomized trials: further insight |
title_sort | risk of selection bias in randomized trials: further insight |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055691/ https://www.ncbi.nlm.nih.gov/pubmed/27717392 http://dx.doi.org/10.1186/s13063-016-1597-5 |
work_keys_str_mv | AT bergervancew riskofselectionbiasinrandomizedtrialsfurtherinsight |