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Risk of selection bias in randomized trials: further insight

The quality of randomization is an under-appreciated facet of trial design. The present piece represents an advance in our collective understanding of how allocation concealment and randomization relate to risk of selection bias in randomized trials, and other measures are also considered. Though th...

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Autor principal: Berger, Vance W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055691/
https://www.ncbi.nlm.nih.gov/pubmed/27717392
http://dx.doi.org/10.1186/s13063-016-1597-5
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author Berger, Vance W.
author_facet Berger, Vance W.
author_sort Berger, Vance W.
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description The quality of randomization is an under-appreciated facet of trial design. The present piece represents an advance in our collective understanding of how allocation concealment and randomization relate to risk of selection bias in randomized trials, and other measures are also considered. Though the overwhelming majority of the advice given is timely and correct, it is more instructive to focus on the relatively narrow sliver of advice that is incorrect (namely, that trials should not stratify by site, and that unrestricted randomization is a solution to the problem of selection bias), so it is in this context that the comments here must be understood. In no way is this intended to be a rebuttal of the excellent work we have before us. Rather, it is a refinement.
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spelling pubmed-50556912016-10-19 Risk of selection bias in randomized trials: further insight Berger, Vance W. Trials Commentary The quality of randomization is an under-appreciated facet of trial design. The present piece represents an advance in our collective understanding of how allocation concealment and randomization relate to risk of selection bias in randomized trials, and other measures are also considered. Though the overwhelming majority of the advice given is timely and correct, it is more instructive to focus on the relatively narrow sliver of advice that is incorrect (namely, that trials should not stratify by site, and that unrestricted randomization is a solution to the problem of selection bias), so it is in this context that the comments here must be understood. In no way is this intended to be a rebuttal of the excellent work we have before us. Rather, it is a refinement. BioMed Central 2016-10-07 /pmc/articles/PMC5055691/ /pubmed/27717392 http://dx.doi.org/10.1186/s13063-016-1597-5 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Berger, Vance W.
Risk of selection bias in randomized trials: further insight
title Risk of selection bias in randomized trials: further insight
title_full Risk of selection bias in randomized trials: further insight
title_fullStr Risk of selection bias in randomized trials: further insight
title_full_unstemmed Risk of selection bias in randomized trials: further insight
title_short Risk of selection bias in randomized trials: further insight
title_sort risk of selection bias in randomized trials: further insight
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055691/
https://www.ncbi.nlm.nih.gov/pubmed/27717392
http://dx.doi.org/10.1186/s13063-016-1597-5
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