Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission and computed tomography

Tuberculosis is classically divided into states of latent infection and active disease. Using combined positron emission and computed tomography in 35 asymptomatic, antiretroviral therapy naïve, HIV-1 infected adults with latent tuberculosis, we identified ten individuals with pulmonary abnormalitie...

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Autores principales: Esmail, H, Lai, RP, Lesosky, M, Wilkinson, KA, Graham, CM, Coussens, AK, Oni, T, Warwick, JM, Said-Hartley, Q, Koegelenberg, CF, Walzl, G, Flynn, JL, Young, DB, Barry, CE, O’Garra, A, Wilkinson, RJ
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055809/
https://www.ncbi.nlm.nih.gov/pubmed/27595321
http://dx.doi.org/10.1038/nm.4161
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author Esmail, H
Lai, RP
Lesosky, M
Wilkinson, KA
Graham, CM
Coussens, AK
Oni, T
Warwick, JM
Said-Hartley, Q
Koegelenberg, CF
Walzl, G
Flynn, JL
Young, DB
Barry, CE
O’Garra, A
Wilkinson, RJ
author_facet Esmail, H
Lai, RP
Lesosky, M
Wilkinson, KA
Graham, CM
Coussens, AK
Oni, T
Warwick, JM
Said-Hartley, Q
Koegelenberg, CF
Walzl, G
Flynn, JL
Young, DB
Barry, CE
O’Garra, A
Wilkinson, RJ
author_sort Esmail, H
collection PubMed
description Tuberculosis is classically divided into states of latent infection and active disease. Using combined positron emission and computed tomography in 35 asymptomatic, antiretroviral therapy naïve, HIV-1 infected adults with latent tuberculosis, we identified ten individuals with pulmonary abnormalities suggestive of subclinical, active disease who were significantly more likely to progress to clinical disease. Our findings challenge the conventional two-state paradigm and may aid future identification of biomarkers predictive of progression.
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spelling pubmed-50558092017-03-05 Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission and computed tomography Esmail, H Lai, RP Lesosky, M Wilkinson, KA Graham, CM Coussens, AK Oni, T Warwick, JM Said-Hartley, Q Koegelenberg, CF Walzl, G Flynn, JL Young, DB Barry, CE O’Garra, A Wilkinson, RJ Nat Med Article Tuberculosis is classically divided into states of latent infection and active disease. Using combined positron emission and computed tomography in 35 asymptomatic, antiretroviral therapy naïve, HIV-1 infected adults with latent tuberculosis, we identified ten individuals with pulmonary abnormalities suggestive of subclinical, active disease who were significantly more likely to progress to clinical disease. Our findings challenge the conventional two-state paradigm and may aid future identification of biomarkers predictive of progression. 2016-09-05 2016-10 /pmc/articles/PMC5055809/ /pubmed/27595321 http://dx.doi.org/10.1038/nm.4161 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Esmail, H
Lai, RP
Lesosky, M
Wilkinson, KA
Graham, CM
Coussens, AK
Oni, T
Warwick, JM
Said-Hartley, Q
Koegelenberg, CF
Walzl, G
Flynn, JL
Young, DB
Barry, CE
O’Garra, A
Wilkinson, RJ
Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission and computed tomography
title Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission and computed tomography
title_full Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission and computed tomography
title_fullStr Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission and computed tomography
title_full_unstemmed Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission and computed tomography
title_short Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission and computed tomography
title_sort characterization of progressive hiv-associated tuberculosis using 2-deoxy-2-[(18)f]fluoro-d-glucose positron emission and computed tomography
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055809/
https://www.ncbi.nlm.nih.gov/pubmed/27595321
http://dx.doi.org/10.1038/nm.4161
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