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Impact of homeobox genes in gastrointestinal cancer

Homeobox genes, including HOX and non-HOX genes, have been identified to be expressed aberrantly in solid tumors. In gastrointestinal (GI) cancers, most studies have focused on the function of non-HOX genes including caudal-related homeobox transcription factor 1 (CDX1) and CDX2. CDX2 is a crucial f...

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Autores principales: Joo, Moon Kyung, Park, Jong-Jae, Chun, Hoon Jai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055856/
https://www.ncbi.nlm.nih.gov/pubmed/27729732
http://dx.doi.org/10.3748/wjg.v22.i37.8247
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author Joo, Moon Kyung
Park, Jong-Jae
Chun, Hoon Jai
author_facet Joo, Moon Kyung
Park, Jong-Jae
Chun, Hoon Jai
author_sort Joo, Moon Kyung
collection PubMed
description Homeobox genes, including HOX and non-HOX genes, have been identified to be expressed aberrantly in solid tumors. In gastrointestinal (GI) cancers, most studies have focused on the function of non-HOX genes including caudal-related homeobox transcription factor 1 (CDX1) and CDX2. CDX2 is a crucial factor in the development of pre-cancerous lesions such as Barrett’s esophagus or intestinal metaplasia in the stomach, and its tumor suppressive role has been investigated in colorectal cancers. Recently, several HOX genes were reported to have specific roles in GI cancers; for example, HOXA13 in esophageal squamous cell cancer and HOXB7 in stomach and colorectal cancers. HOXD10 is upregulated in colorectal cancer while it is silenced epigenetically in gastric cancer. Thus, it is essential to examine the differential expression pattern of various homeobox genes in specific tumor types or cell lineages, and understand their underlying mechanisms. In this review, we summarize the available research on homeobox genes and present their potential value for the prediction of prognosis in GI cancers.
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spelling pubmed-50558562016-10-11 Impact of homeobox genes in gastrointestinal cancer Joo, Moon Kyung Park, Jong-Jae Chun, Hoon Jai World J Gastroenterol Editorial Homeobox genes, including HOX and non-HOX genes, have been identified to be expressed aberrantly in solid tumors. In gastrointestinal (GI) cancers, most studies have focused on the function of non-HOX genes including caudal-related homeobox transcription factor 1 (CDX1) and CDX2. CDX2 is a crucial factor in the development of pre-cancerous lesions such as Barrett’s esophagus or intestinal metaplasia in the stomach, and its tumor suppressive role has been investigated in colorectal cancers. Recently, several HOX genes were reported to have specific roles in GI cancers; for example, HOXA13 in esophageal squamous cell cancer and HOXB7 in stomach and colorectal cancers. HOXD10 is upregulated in colorectal cancer while it is silenced epigenetically in gastric cancer. Thus, it is essential to examine the differential expression pattern of various homeobox genes in specific tumor types or cell lineages, and understand their underlying mechanisms. In this review, we summarize the available research on homeobox genes and present their potential value for the prediction of prognosis in GI cancers. Baishideng Publishing Group Inc 2016-10-07 2016-10-07 /pmc/articles/PMC5055856/ /pubmed/27729732 http://dx.doi.org/10.3748/wjg.v22.i37.8247 Text en ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Editorial
Joo, Moon Kyung
Park, Jong-Jae
Chun, Hoon Jai
Impact of homeobox genes in gastrointestinal cancer
title Impact of homeobox genes in gastrointestinal cancer
title_full Impact of homeobox genes in gastrointestinal cancer
title_fullStr Impact of homeobox genes in gastrointestinal cancer
title_full_unstemmed Impact of homeobox genes in gastrointestinal cancer
title_short Impact of homeobox genes in gastrointestinal cancer
title_sort impact of homeobox genes in gastrointestinal cancer
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055856/
https://www.ncbi.nlm.nih.gov/pubmed/27729732
http://dx.doi.org/10.3748/wjg.v22.i37.8247
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