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Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?

Oxidative stress is viewed as an imbalance between the production of reactive oxygen species (ROS) and their elimination by protective mechanisms, which can lead to chronic inflammation. Oxidative stress can activate a variety of transcription factors, which lead to the differential expression of so...

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Autores principales: Hussain, Tarique, Tan, Bie, Yin, Yulong, Blachier, Francois, Tossou, Myrlene C. B., Rahu, Najma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055983/
https://www.ncbi.nlm.nih.gov/pubmed/27738491
http://dx.doi.org/10.1155/2016/7432797
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author Hussain, Tarique
Tan, Bie
Yin, Yulong
Blachier, Francois
Tossou, Myrlene C. B.
Rahu, Najma
author_facet Hussain, Tarique
Tan, Bie
Yin, Yulong
Blachier, Francois
Tossou, Myrlene C. B.
Rahu, Najma
author_sort Hussain, Tarique
collection PubMed
description Oxidative stress is viewed as an imbalance between the production of reactive oxygen species (ROS) and their elimination by protective mechanisms, which can lead to chronic inflammation. Oxidative stress can activate a variety of transcription factors, which lead to the differential expression of some genes involved in inflammatory pathways. The inflammation triggered by oxidative stress is the cause of many chronic diseases. Polyphenols have been proposed to be useful as adjuvant therapy for their potential anti-inflammatory effect, associated with antioxidant activity, and inhibition of enzymes involved in the production of eicosanoids. This review aims at exploring the properties of polyphenols in anti-inflammation and oxidation and the mechanisms of polyphenols inhibiting molecular signaling pathways which are activated by oxidative stress, as well as the possible roles of polyphenols in inflammation-mediated chronic disorders. Such data can be helpful for the development of future antioxidant therapeutics and new anti-inflammatory drugs.
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spelling pubmed-50559832016-10-13 Oxidative Stress and Inflammation: What Polyphenols Can Do for Us? Hussain, Tarique Tan, Bie Yin, Yulong Blachier, Francois Tossou, Myrlene C. B. Rahu, Najma Oxid Med Cell Longev Review Article Oxidative stress is viewed as an imbalance between the production of reactive oxygen species (ROS) and their elimination by protective mechanisms, which can lead to chronic inflammation. Oxidative stress can activate a variety of transcription factors, which lead to the differential expression of some genes involved in inflammatory pathways. The inflammation triggered by oxidative stress is the cause of many chronic diseases. Polyphenols have been proposed to be useful as adjuvant therapy for their potential anti-inflammatory effect, associated with antioxidant activity, and inhibition of enzymes involved in the production of eicosanoids. This review aims at exploring the properties of polyphenols in anti-inflammation and oxidation and the mechanisms of polyphenols inhibiting molecular signaling pathways which are activated by oxidative stress, as well as the possible roles of polyphenols in inflammation-mediated chronic disorders. Such data can be helpful for the development of future antioxidant therapeutics and new anti-inflammatory drugs. Hindawi Publishing Corporation 2016 2016-09-22 /pmc/articles/PMC5055983/ /pubmed/27738491 http://dx.doi.org/10.1155/2016/7432797 Text en Copyright © 2016 Tarique Hussain et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Hussain, Tarique
Tan, Bie
Yin, Yulong
Blachier, Francois
Tossou, Myrlene C. B.
Rahu, Najma
Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?
title Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?
title_full Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?
title_fullStr Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?
title_full_unstemmed Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?
title_short Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?
title_sort oxidative stress and inflammation: what polyphenols can do for us?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055983/
https://www.ncbi.nlm.nih.gov/pubmed/27738491
http://dx.doi.org/10.1155/2016/7432797
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