Lysosomal solute carrier transporters gain momentum in research

Emerging evidence indicates that lysosome function extends beyond macromolecular degradation. Genetic and functional defects in components of the lysosomal transport machinery cause lysosomal storage disorders implicating the lysosomal solute carrier (SLC) transporters as essential to vital cell pro...

Descripción completa

Detalles Bibliográficos
Autores principales: Bissa, B, Beedle, AM, Govindarajan, R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Discovery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056150/
https://www.ncbi.nlm.nih.gov/pubmed/27530302
http://dx.doi.org/10.1002/cpt.450
_version_ 1782458842444988416
author Bissa, B
Beedle, AM
Govindarajan, R
author_facet Bissa, B
Beedle, AM
Govindarajan, R
author_sort Bissa, B
collection PubMed
description Emerging evidence indicates that lysosome function extends beyond macromolecular degradation. Genetic and functional defects in components of the lysosomal transport machinery cause lysosomal storage disorders implicating the lysosomal solute carrier (SLC) transporters as essential to vital cell processes. The pathophysiology and therapeutic potential of lysosomal SLC transporters are highlighted here, focusing on recent discoveries in autophagic amino acid sensing (SLC38A9), phagocytic regulation in macrophages (SLC29A3, SLC15A3/A4), adenosine triphosphate (ATP) exocytosis in neurotransmission (SLC17A9), and lysosomal transport of maytansine catabolites into the cytoplasm (SLC46A3).
format Online
Article
Text
id pubmed-5056150
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-50561502016-11-14 Lysosomal solute carrier transporters gain momentum in research Bissa, B Beedle, AM Govindarajan, R Clin Pharmacol Ther Discovery Emerging evidence indicates that lysosome function extends beyond macromolecular degradation. Genetic and functional defects in components of the lysosomal transport machinery cause lysosomal storage disorders implicating the lysosomal solute carrier (SLC) transporters as essential to vital cell processes. The pathophysiology and therapeutic potential of lysosomal SLC transporters are highlighted here, focusing on recent discoveries in autophagic amino acid sensing (SLC38A9), phagocytic regulation in macrophages (SLC29A3, SLC15A3/A4), adenosine triphosphate (ATP) exocytosis in neurotransmission (SLC17A9), and lysosomal transport of maytansine catabolites into the cytoplasm (SLC46A3). John Wiley and Sons Inc. 2016-09-15 2016-11 /pmc/articles/PMC5056150/ /pubmed/27530302 http://dx.doi.org/10.1002/cpt.450 Text en © 2016 The Authors Clinical Pharmacology & Therapeutics published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Discovery
Bissa, B
Beedle, AM
Govindarajan, R
Lysosomal solute carrier transporters gain momentum in research
title Lysosomal solute carrier transporters gain momentum in research
title_full Lysosomal solute carrier transporters gain momentum in research
title_fullStr Lysosomal solute carrier transporters gain momentum in research
title_full_unstemmed Lysosomal solute carrier transporters gain momentum in research
title_short Lysosomal solute carrier transporters gain momentum in research
title_sort lysosomal solute carrier transporters gain momentum in research
topic Discovery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056150/
https://www.ncbi.nlm.nih.gov/pubmed/27530302
http://dx.doi.org/10.1002/cpt.450
work_keys_str_mv AT bissab lysosomalsolutecarriertransportersgainmomentuminresearch
AT beedleam lysosomalsolutecarriertransportersgainmomentuminresearch
AT govindarajanr lysosomalsolutecarriertransportersgainmomentuminresearch

Ejemplares similares