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Effect of Myoinositol and Antioxidants on Sperm Quality in Men with Metabolic Syndrome

This prospective longitudinal study investigated the effects of a dietary supplement in patients affected by reduced sperm motility (asthenospermic males) with metabolic syndrome. The product tested was Andrositol®, which contains myoinositol (MI) as principal compound, in association with other mol...

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Autores principales: Montanino Oliva, Mario, Minutolo, Elisa, Lippa, Assunta, Iaconianni, Paola, Vaiarelli, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056296/
https://www.ncbi.nlm.nih.gov/pubmed/27752262
http://dx.doi.org/10.1155/2016/1674950
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author Montanino Oliva, Mario
Minutolo, Elisa
Lippa, Assunta
Iaconianni, Paola
Vaiarelli, Alberto
author_facet Montanino Oliva, Mario
Minutolo, Elisa
Lippa, Assunta
Iaconianni, Paola
Vaiarelli, Alberto
author_sort Montanino Oliva, Mario
collection PubMed
description This prospective longitudinal study investigated the effects of a dietary supplement in patients affected by reduced sperm motility (asthenospermic males) with metabolic syndrome. The product tested was Andrositol®, which contains myoinositol (MI) as principal compound, in association with other molecules, and the parameters evaluated were semen characteristics as well as hormone and metabolic profiles. The inclusion criteria were subjects aged over 18 years, with asthenospermia and metabolic syndrome. The exclusion criteria were presence of cryptorchidism, varicocele, and prostatitis. For this study, 45 males who had such features were enrolled. Their selection was made according to the 2010 World Health Organization (WHO) criteria (5th Edition) for the Evaluation of Human Semen. Hormone and metabolic profiles and semen parameters were assessed at the beginning of the study and after three months of treatment with Andrositol. The differences between the values before and after the supplementation were found statistically significant. Andrositol normalized the metabolic profile of these patients, improving their insulin sensitivity. Moreover, testosterone levels were increased and the semen characteristics, such as sperm concentration, motility, and morphology, highly improved. In conclusion, the association of MI with other molecules (micronutrients and vitamins) could be an effective therapy for metabolic disorders, as well as hormonal and spermatic changes responsible for male infertility.
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spelling pubmed-50562962016-10-17 Effect of Myoinositol and Antioxidants on Sperm Quality in Men with Metabolic Syndrome Montanino Oliva, Mario Minutolo, Elisa Lippa, Assunta Iaconianni, Paola Vaiarelli, Alberto Int J Endocrinol Clinical Study This prospective longitudinal study investigated the effects of a dietary supplement in patients affected by reduced sperm motility (asthenospermic males) with metabolic syndrome. The product tested was Andrositol®, which contains myoinositol (MI) as principal compound, in association with other molecules, and the parameters evaluated were semen characteristics as well as hormone and metabolic profiles. The inclusion criteria were subjects aged over 18 years, with asthenospermia and metabolic syndrome. The exclusion criteria were presence of cryptorchidism, varicocele, and prostatitis. For this study, 45 males who had such features were enrolled. Their selection was made according to the 2010 World Health Organization (WHO) criteria (5th Edition) for the Evaluation of Human Semen. Hormone and metabolic profiles and semen parameters were assessed at the beginning of the study and after three months of treatment with Andrositol. The differences between the values before and after the supplementation were found statistically significant. Andrositol normalized the metabolic profile of these patients, improving their insulin sensitivity. Moreover, testosterone levels were increased and the semen characteristics, such as sperm concentration, motility, and morphology, highly improved. In conclusion, the association of MI with other molecules (micronutrients and vitamins) could be an effective therapy for metabolic disorders, as well as hormonal and spermatic changes responsible for male infertility. Hindawi Publishing Corporation 2016 2016-09-26 /pmc/articles/PMC5056296/ /pubmed/27752262 http://dx.doi.org/10.1155/2016/1674950 Text en Copyright © 2016 Mario Montanino Oliva et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Montanino Oliva, Mario
Minutolo, Elisa
Lippa, Assunta
Iaconianni, Paola
Vaiarelli, Alberto
Effect of Myoinositol and Antioxidants on Sperm Quality in Men with Metabolic Syndrome
title Effect of Myoinositol and Antioxidants on Sperm Quality in Men with Metabolic Syndrome
title_full Effect of Myoinositol and Antioxidants on Sperm Quality in Men with Metabolic Syndrome
title_fullStr Effect of Myoinositol and Antioxidants on Sperm Quality in Men with Metabolic Syndrome
title_full_unstemmed Effect of Myoinositol and Antioxidants on Sperm Quality in Men with Metabolic Syndrome
title_short Effect of Myoinositol and Antioxidants on Sperm Quality in Men with Metabolic Syndrome
title_sort effect of myoinositol and antioxidants on sperm quality in men with metabolic syndrome
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056296/
https://www.ncbi.nlm.nih.gov/pubmed/27752262
http://dx.doi.org/10.1155/2016/1674950
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