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Timely antiretroviral prophylaxis during pregnancy effectively reduces HIV mother-to-child transmission in eight counties in China: a prospective study during 2004–2011

This study investigates the improvement of the prevention of mother-to-child transmission (PMTCT) of Human Immunodeficiency Virus (HIV) in China during 2004–2011. A clinic-based prospective study was conducted among HIV-positive pregnant women and their children in eight counties across China. Assoc...

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Autores principales: Wang, Qian, Wang, Linhong, Fang, Liwen, Wang, Ailing, Jin, Xi, Wang, Fang, Wang, Xiaoyan, Qiao, Yaping, Sullivan, Sheena G., Rutherford, Shannon, Zhang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056360/
https://www.ncbi.nlm.nih.gov/pubmed/27721453
http://dx.doi.org/10.1038/srep34526
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author Wang, Qian
Wang, Linhong
Fang, Liwen
Wang, Ailing
Jin, Xi
Wang, Fang
Wang, Xiaoyan
Qiao, Yaping
Sullivan, Sheena G.
Rutherford, Shannon
Zhang, Lei
author_facet Wang, Qian
Wang, Linhong
Fang, Liwen
Wang, Ailing
Jin, Xi
Wang, Fang
Wang, Xiaoyan
Qiao, Yaping
Sullivan, Sheena G.
Rutherford, Shannon
Zhang, Lei
author_sort Wang, Qian
collection PubMed
description This study investigates the improvement of the prevention of mother-to-child transmission (PMTCT) of Human Immunodeficiency Virus (HIV) in China during 2004–2011. A clinic-based prospective study was conducted among HIV-positive pregnant women and their children in eight counties across China. Associated factors of mother-to-child transmission were analyzed using regression analysis. A total of 1,387 HIV+ pregnant women and 1,377 HIV-exposed infants were enrolled. The proportion of pregnant women who received HIV testing increased significantly from 45.1% to 98.9% during 2004–2011. Among whom, the proportion that received antiretroviral (ARV) prophylaxis increased from 61% to 96%, and the corresponding coverage in children increased from 85% to 97% during the same period. In contrast, single-dose nevirapine treatment during delivery declined substantially from 97.9% to 12.7%. Vertical transmission of HIV declined from 11.1% (95% confidence interval [CI]: 5.7–23.3%) in 2004 to 1.2% (95% CI: 0.1–5.8%) in 2011. Women who had a vaginal delivery (compared to emergency caesarian section (odds ratio [OR] = 0.46; 0.23–0.96)) and mothers on multi-ARVs (OR = 0.11; 0.04–0.29) were less likely to transmit HIV to their newborns. Increasing HIV screening enabled timely HIV care and prophylaxis to reduce vertical transmission of HIV. Early and consistent treatment with multi-ARVs during pregnancy is vital for PMTCT.
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spelling pubmed-50563602016-10-19 Timely antiretroviral prophylaxis during pregnancy effectively reduces HIV mother-to-child transmission in eight counties in China: a prospective study during 2004–2011 Wang, Qian Wang, Linhong Fang, Liwen Wang, Ailing Jin, Xi Wang, Fang Wang, Xiaoyan Qiao, Yaping Sullivan, Sheena G. Rutherford, Shannon Zhang, Lei Sci Rep Article This study investigates the improvement of the prevention of mother-to-child transmission (PMTCT) of Human Immunodeficiency Virus (HIV) in China during 2004–2011. A clinic-based prospective study was conducted among HIV-positive pregnant women and their children in eight counties across China. Associated factors of mother-to-child transmission were analyzed using regression analysis. A total of 1,387 HIV+ pregnant women and 1,377 HIV-exposed infants were enrolled. The proportion of pregnant women who received HIV testing increased significantly from 45.1% to 98.9% during 2004–2011. Among whom, the proportion that received antiretroviral (ARV) prophylaxis increased from 61% to 96%, and the corresponding coverage in children increased from 85% to 97% during the same period. In contrast, single-dose nevirapine treatment during delivery declined substantially from 97.9% to 12.7%. Vertical transmission of HIV declined from 11.1% (95% confidence interval [CI]: 5.7–23.3%) in 2004 to 1.2% (95% CI: 0.1–5.8%) in 2011. Women who had a vaginal delivery (compared to emergency caesarian section (odds ratio [OR] = 0.46; 0.23–0.96)) and mothers on multi-ARVs (OR = 0.11; 0.04–0.29) were less likely to transmit HIV to their newborns. Increasing HIV screening enabled timely HIV care and prophylaxis to reduce vertical transmission of HIV. Early and consistent treatment with multi-ARVs during pregnancy is vital for PMTCT. Nature Publishing Group 2016-10-10 /pmc/articles/PMC5056360/ /pubmed/27721453 http://dx.doi.org/10.1038/srep34526 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Wang, Qian
Wang, Linhong
Fang, Liwen
Wang, Ailing
Jin, Xi
Wang, Fang
Wang, Xiaoyan
Qiao, Yaping
Sullivan, Sheena G.
Rutherford, Shannon
Zhang, Lei
Timely antiretroviral prophylaxis during pregnancy effectively reduces HIV mother-to-child transmission in eight counties in China: a prospective study during 2004–2011
title Timely antiretroviral prophylaxis during pregnancy effectively reduces HIV mother-to-child transmission in eight counties in China: a prospective study during 2004–2011
title_full Timely antiretroviral prophylaxis during pregnancy effectively reduces HIV mother-to-child transmission in eight counties in China: a prospective study during 2004–2011
title_fullStr Timely antiretroviral prophylaxis during pregnancy effectively reduces HIV mother-to-child transmission in eight counties in China: a prospective study during 2004–2011
title_full_unstemmed Timely antiretroviral prophylaxis during pregnancy effectively reduces HIV mother-to-child transmission in eight counties in China: a prospective study during 2004–2011
title_short Timely antiretroviral prophylaxis during pregnancy effectively reduces HIV mother-to-child transmission in eight counties in China: a prospective study during 2004–2011
title_sort timely antiretroviral prophylaxis during pregnancy effectively reduces hiv mother-to-child transmission in eight counties in china: a prospective study during 2004–2011
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056360/
https://www.ncbi.nlm.nih.gov/pubmed/27721453
http://dx.doi.org/10.1038/srep34526
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