Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide

In the innate immune system, pattern recognition receptors (PRRs) specifically recognize ligands derived from bacteria or viruses, to trigger the responsible downstream pathways. DEAD box protein 41 (DDX41) is an intracellular PRR that triggers the downstream pathway involving the adapter STING, the...

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Detalles Bibliográficos
Autores principales: Omura, Hiroki, Oikawa, Daisuke, Nakane, Takanori, Kato, Megumi, Ishii, Ryohei, Ishitani, Ryuichiro, Tokunaga, Fuminori, Nureki, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056382/
https://www.ncbi.nlm.nih.gov/pubmed/27721487
http://dx.doi.org/10.1038/srep34756

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