IGF-I induces senescence of hepatic stellate cells and limits fibrosis in a p53-dependent manner

Hepatic fibrosis in nonalcoholic steatohepatitis (NASH) and cirrhosis determines patient prognosis; however, effective treatment for fibrosis has not been established. Oxidative stress and inflammation activate hepatic stellate cells (HSCs) and promote fibrosis. In contrast, cellular senescence inhi...

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Detalles Bibliográficos
Autores principales: Nishizawa, Hitoshi, Iguchi, Genzo, Fukuoka, Hidenori, Takahashi, Michiko, Suda, Kentaro, Bando, Hironori, Matsumoto, Ryusaku, Yoshida, Kenichi, Odake, Yukiko, Ogawa, Wataru, Takahashi, Yutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056388/
https://www.ncbi.nlm.nih.gov/pubmed/27721459
http://dx.doi.org/10.1038/srep34605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056388/
https://www.ncbi.nlm.nih.gov/pubmed/27721459
http://dx.doi.org/10.1038/srep34605

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