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Redefining the BH3 Death Domain as a ‘Short Linear Motif’

B cell lymphoma-2 (BCL-2)-related proteins control programmed cell death through a complex network of protein–protein interactions mediated by BCL-2 homology 3 (BH3) domains. Given their roles as dynamic linchpins, the discovery of novel BH3-containing proteins has attracted considerable attention....

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Detalles Bibliográficos
Autores principales: Aouacheria, Abdel, Combet, Christophe, Tompa, Peter, Hardwick, J. Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056427/
https://www.ncbi.nlm.nih.gov/pubmed/26541461
http://dx.doi.org/10.1016/j.tibs.2015.09.007
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author Aouacheria, Abdel
Combet, Christophe
Tompa, Peter
Hardwick, J. Marie
author_facet Aouacheria, Abdel
Combet, Christophe
Tompa, Peter
Hardwick, J. Marie
author_sort Aouacheria, Abdel
collection PubMed
description B cell lymphoma-2 (BCL-2)-related proteins control programmed cell death through a complex network of protein–protein interactions mediated by BCL-2 homology 3 (BH3) domains. Given their roles as dynamic linchpins, the discovery of novel BH3-containing proteins has attracted considerable attention. However, without a clearly defined BH3 signature sequence the BCL-2 family has expanded to include a nebulous group of nonhomologous BH3-only proteins, now justified by an intriguing twist. We present evidence that BH3s from both ordered and disordered proteins represent a new class of short linear motifs (SLiMs) or molecular recognition features (MoRFs) and are diverse in their evolutionary histories. The implied corollaries are that BH3s have a broad phylogenetic distribution and could potentially bind to non-BCL-2-like structural domains with distinct functions.
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spelling pubmed-50564272016-12-01 Redefining the BH3 Death Domain as a ‘Short Linear Motif’ Aouacheria, Abdel Combet, Christophe Tompa, Peter Hardwick, J. Marie Trends Biochem Sci Opinion B cell lymphoma-2 (BCL-2)-related proteins control programmed cell death through a complex network of protein–protein interactions mediated by BCL-2 homology 3 (BH3) domains. Given their roles as dynamic linchpins, the discovery of novel BH3-containing proteins has attracted considerable attention. However, without a clearly defined BH3 signature sequence the BCL-2 family has expanded to include a nebulous group of nonhomologous BH3-only proteins, now justified by an intriguing twist. We present evidence that BH3s from both ordered and disordered proteins represent a new class of short linear motifs (SLiMs) or molecular recognition features (MoRFs) and are diverse in their evolutionary histories. The implied corollaries are that BH3s have a broad phylogenetic distribution and could potentially bind to non-BCL-2-like structural domains with distinct functions. Elsevier Ltd. 2015-12 2015-11-03 /pmc/articles/PMC5056427/ /pubmed/26541461 http://dx.doi.org/10.1016/j.tibs.2015.09.007 Text en Copyright © 2015 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Opinion
Aouacheria, Abdel
Combet, Christophe
Tompa, Peter
Hardwick, J. Marie
Redefining the BH3 Death Domain as a ‘Short Linear Motif’
title Redefining the BH3 Death Domain as a ‘Short Linear Motif’
title_full Redefining the BH3 Death Domain as a ‘Short Linear Motif’
title_fullStr Redefining the BH3 Death Domain as a ‘Short Linear Motif’
title_full_unstemmed Redefining the BH3 Death Domain as a ‘Short Linear Motif’
title_short Redefining the BH3 Death Domain as a ‘Short Linear Motif’
title_sort redefining the bh3 death domain as a ‘short linear motif’
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056427/
https://www.ncbi.nlm.nih.gov/pubmed/26541461
http://dx.doi.org/10.1016/j.tibs.2015.09.007
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