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Chemotaxis towards autoinducer 2 mediates autoaggregation in Escherichia coli
Bacteria communicate by producing and sensing extracellular signal molecules called autoinducers. Such intercellular signalling, known as quorum sensing, allows bacteria to coordinate and synchronize behavioural responses at high cell densities. Autoinducer 2 (AI-2) is the only known quorum-sensing...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056481/ https://www.ncbi.nlm.nih.gov/pubmed/27687245 http://dx.doi.org/10.1038/ncomms12984 |
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author | Laganenka, Leanid Colin, Remy Sourjik, Victor |
author_facet | Laganenka, Leanid Colin, Remy Sourjik, Victor |
author_sort | Laganenka, Leanid |
collection | PubMed |
description | Bacteria communicate by producing and sensing extracellular signal molecules called autoinducers. Such intercellular signalling, known as quorum sensing, allows bacteria to coordinate and synchronize behavioural responses at high cell densities. Autoinducer 2 (AI-2) is the only known quorum-sensing molecule produced by Escherichia coli but its physiological role remains elusive, although it is known to regulate biofilm formation and virulence in other bacterial species. Here we show that chemotaxis towards self-produced AI-2 can mediate collective behaviour—autoaggregation—of E. coli. Autoaggregation requires motility and is strongly enhanced by chemotaxis to AI-2 at physiological cell densities. These effects are observed regardless whether cell–cell interactions under particular growth conditions are mediated by the major E. coli adhesin (antigen 43) or by curli fibres. Furthermore, AI-2-dependent autoaggregation enhances bacterial stress resistance and promotes biofilm formation. |
format | Online Article Text |
id | pubmed-5056481 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-50564812016-10-24 Chemotaxis towards autoinducer 2 mediates autoaggregation in Escherichia coli Laganenka, Leanid Colin, Remy Sourjik, Victor Nat Commun Article Bacteria communicate by producing and sensing extracellular signal molecules called autoinducers. Such intercellular signalling, known as quorum sensing, allows bacteria to coordinate and synchronize behavioural responses at high cell densities. Autoinducer 2 (AI-2) is the only known quorum-sensing molecule produced by Escherichia coli but its physiological role remains elusive, although it is known to regulate biofilm formation and virulence in other bacterial species. Here we show that chemotaxis towards self-produced AI-2 can mediate collective behaviour—autoaggregation—of E. coli. Autoaggregation requires motility and is strongly enhanced by chemotaxis to AI-2 at physiological cell densities. These effects are observed regardless whether cell–cell interactions under particular growth conditions are mediated by the major E. coli adhesin (antigen 43) or by curli fibres. Furthermore, AI-2-dependent autoaggregation enhances bacterial stress resistance and promotes biofilm formation. Nature Publishing Group 2016-09-30 /pmc/articles/PMC5056481/ /pubmed/27687245 http://dx.doi.org/10.1038/ncomms12984 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Laganenka, Leanid Colin, Remy Sourjik, Victor Chemotaxis towards autoinducer 2 mediates autoaggregation in Escherichia coli |
title | Chemotaxis towards autoinducer 2 mediates autoaggregation in Escherichia coli |
title_full | Chemotaxis towards autoinducer 2 mediates autoaggregation in Escherichia coli |
title_fullStr | Chemotaxis towards autoinducer 2 mediates autoaggregation in Escherichia coli |
title_full_unstemmed | Chemotaxis towards autoinducer 2 mediates autoaggregation in Escherichia coli |
title_short | Chemotaxis towards autoinducer 2 mediates autoaggregation in Escherichia coli |
title_sort | chemotaxis towards autoinducer 2 mediates autoaggregation in escherichia coli |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056481/ https://www.ncbi.nlm.nih.gov/pubmed/27687245 http://dx.doi.org/10.1038/ncomms12984 |
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