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Anti-thrombotic agents derived from snake venom proteins

Snake venoms affect blood coagulation and platelet function in a complex manner. However, two classes of venom proteins, snaclecs and disintegrins have been shown to specifically target receptors including GPIb, α2β1, GPVI, CLEC-2 and integrins αIIbβ3, αvβ3, α5β1 expressed on platelets, endothelial...

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Autores principales: Huang, Tur-Fu, Hsu, Chun-Chieh, Kuo, Yu-Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056499/
https://www.ncbi.nlm.nih.gov/pubmed/27766044
http://dx.doi.org/10.1186/s12959-016-0113-1
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author Huang, Tur-Fu
Hsu, Chun-Chieh
Kuo, Yu-Ju
author_facet Huang, Tur-Fu
Hsu, Chun-Chieh
Kuo, Yu-Ju
author_sort Huang, Tur-Fu
collection PubMed
description Snake venoms affect blood coagulation and platelet function in a complex manner. However, two classes of venom proteins, snaclecs and disintegrins have been shown to specifically target receptors including GPIb, α2β1, GPVI, CLEC-2 and integrins αIIbβ3, αvβ3, α5β1 expressed on platelets, endothelial cells, phagocytes, tumor cells, thus affecting cell-matrices and cell-cell interactions. Here, we focus on disintegrins, a class of low molecular mass Arg-Gly-Asp(RGD)/Lys-Gly-Asp(KGD)-containing, cysteine-rich polypeptide derived from various viper snake venoms. This review describes the potential applications of disintegrins in field of integrin-related diseases, especially arterial thrombosis, angiogenesis, tumor progression and septic inflammation. In addition, a novel RGD-containing disintegrin TMV-7 is being developed as a safer antithrombotic agent with minimal side effects, such as thrombocytopenia and bleeding.
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spelling pubmed-50564992016-10-20 Anti-thrombotic agents derived from snake venom proteins Huang, Tur-Fu Hsu, Chun-Chieh Kuo, Yu-Ju Thromb J Review Snake venoms affect blood coagulation and platelet function in a complex manner. However, two classes of venom proteins, snaclecs and disintegrins have been shown to specifically target receptors including GPIb, α2β1, GPVI, CLEC-2 and integrins αIIbβ3, αvβ3, α5β1 expressed on platelets, endothelial cells, phagocytes, tumor cells, thus affecting cell-matrices and cell-cell interactions. Here, we focus on disintegrins, a class of low molecular mass Arg-Gly-Asp(RGD)/Lys-Gly-Asp(KGD)-containing, cysteine-rich polypeptide derived from various viper snake venoms. This review describes the potential applications of disintegrins in field of integrin-related diseases, especially arterial thrombosis, angiogenesis, tumor progression and septic inflammation. In addition, a novel RGD-containing disintegrin TMV-7 is being developed as a safer antithrombotic agent with minimal side effects, such as thrombocytopenia and bleeding. BioMed Central 2016-10-04 /pmc/articles/PMC5056499/ /pubmed/27766044 http://dx.doi.org/10.1186/s12959-016-0113-1 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Huang, Tur-Fu
Hsu, Chun-Chieh
Kuo, Yu-Ju
Anti-thrombotic agents derived from snake venom proteins
title Anti-thrombotic agents derived from snake venom proteins
title_full Anti-thrombotic agents derived from snake venom proteins
title_fullStr Anti-thrombotic agents derived from snake venom proteins
title_full_unstemmed Anti-thrombotic agents derived from snake venom proteins
title_short Anti-thrombotic agents derived from snake venom proteins
title_sort anti-thrombotic agents derived from snake venom proteins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056499/
https://www.ncbi.nlm.nih.gov/pubmed/27766044
http://dx.doi.org/10.1186/s12959-016-0113-1
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