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Molecular dynamics simulations and docking enable to explore the biophysical factors controlling the yields of engineered nanobodies
Nanobodies (VHHs) have proved to be valuable substitutes of conventional antibodies for molecular recognition. Their small size represents a precious advantage for rational mutagenesis based on modelling. Here we address the problem of predicting how Camelidae nanobody sequences can tolerate mutatio...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056509/ https://www.ncbi.nlm.nih.gov/pubmed/27721441 http://dx.doi.org/10.1038/srep34869 |