Cargando…

The Role of Visceral Hypersensitivity in Irritable Bowel Syndrome: Pharmacological Targets and Novel Treatments

Irritable bowel syndrome (IBS) is the most common disorder referred to gastroenterologists and is characterized by altered bowel habits, abdominal pain, and bloating. Visceral hypersensitivity (VH) is a multifactorial process that may occur within the peripheral or central nervous systems and plays...

Descripción completa

Detalles Bibliográficos
Autores principales: Farzaei, Mohammad H, Bahramsoltani, Roodabeh, Abdollahi, Mohammad, Rahimi, Roja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Neurogastroenterology and Motility 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056566/
https://www.ncbi.nlm.nih.gov/pubmed/27431236
http://dx.doi.org/10.5056/jnm16001
_version_ 1782458927366012928
author Farzaei, Mohammad H
Bahramsoltani, Roodabeh
Abdollahi, Mohammad
Rahimi, Roja
author_facet Farzaei, Mohammad H
Bahramsoltani, Roodabeh
Abdollahi, Mohammad
Rahimi, Roja
author_sort Farzaei, Mohammad H
collection PubMed
description Irritable bowel syndrome (IBS) is the most common disorder referred to gastroenterologists and is characterized by altered bowel habits, abdominal pain, and bloating. Visceral hypersensitivity (VH) is a multifactorial process that may occur within the peripheral or central nervous systems and plays a principal role in the etiology of IBS symptoms. The pharmacological studies on selective drugs based on targeting specific ligands can provide novel therapies for modulation of persistent visceral hyperalgesia. The current paper reviews the cellular and molecular mechanisms underlying therapeutic targeting for providing future drugs to protect or treat visceroperception and pain sensitization in IBS patients. There are a wide range of mediators and receptors participating in visceral pain perception amongst which substances targeting afferent receptors are attractive sources of novel drugs. Novel therapeutic targets for the management of VH include compounds which alter gut-brain pathways and local neuroimmune pathways. Molecular mediators and receptors participating in pain perception and visceroperception include histamine-1 receptors, serotonin (5-hydrodytryptamine) receptors, transient receptor potential vanilloid type I, tachykinins ligands, opioid receptors, voltage-gated channels, tyrosine receptor kinase receptors, protease-activated receptors, adrenergic system ligands, cannabinoid receptors, sex hormones, and glutamate receptors which are discussed in the current review. Moreover, several plant-derived natural compounds with potential to alleviate VH in IBS have been highlighted. VH has an important role in the pathology and severity of complications in IBS. Therefore, managing VH can remarkably modulate the symptoms of IBS. More preclinical and clinical investigations are needed to provide efficacious and targeted medicines for the management of VH.
format Online
Article
Text
id pubmed-5056566
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Korean Society of Neurogastroenterology and Motility
record_format MEDLINE/PubMed
spelling pubmed-50565662016-10-11 The Role of Visceral Hypersensitivity in Irritable Bowel Syndrome: Pharmacological Targets and Novel Treatments Farzaei, Mohammad H Bahramsoltani, Roodabeh Abdollahi, Mohammad Rahimi, Roja J Neurogastroenterol Motil Review Irritable bowel syndrome (IBS) is the most common disorder referred to gastroenterologists and is characterized by altered bowel habits, abdominal pain, and bloating. Visceral hypersensitivity (VH) is a multifactorial process that may occur within the peripheral or central nervous systems and plays a principal role in the etiology of IBS symptoms. The pharmacological studies on selective drugs based on targeting specific ligands can provide novel therapies for modulation of persistent visceral hyperalgesia. The current paper reviews the cellular and molecular mechanisms underlying therapeutic targeting for providing future drugs to protect or treat visceroperception and pain sensitization in IBS patients. There are a wide range of mediators and receptors participating in visceral pain perception amongst which substances targeting afferent receptors are attractive sources of novel drugs. Novel therapeutic targets for the management of VH include compounds which alter gut-brain pathways and local neuroimmune pathways. Molecular mediators and receptors participating in pain perception and visceroperception include histamine-1 receptors, serotonin (5-hydrodytryptamine) receptors, transient receptor potential vanilloid type I, tachykinins ligands, opioid receptors, voltage-gated channels, tyrosine receptor kinase receptors, protease-activated receptors, adrenergic system ligands, cannabinoid receptors, sex hormones, and glutamate receptors which are discussed in the current review. Moreover, several plant-derived natural compounds with potential to alleviate VH in IBS have been highlighted. VH has an important role in the pathology and severity of complications in IBS. Therefore, managing VH can remarkably modulate the symptoms of IBS. More preclinical and clinical investigations are needed to provide efficacious and targeted medicines for the management of VH. Korean Society of Neurogastroenterology and Motility 2016-10 2016-10-01 /pmc/articles/PMC5056566/ /pubmed/27431236 http://dx.doi.org/10.5056/jnm16001 Text en © 2016 The Korean Society of Neurogastroenterology and Motility This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Farzaei, Mohammad H
Bahramsoltani, Roodabeh
Abdollahi, Mohammad
Rahimi, Roja
The Role of Visceral Hypersensitivity in Irritable Bowel Syndrome: Pharmacological Targets and Novel Treatments
title The Role of Visceral Hypersensitivity in Irritable Bowel Syndrome: Pharmacological Targets and Novel Treatments
title_full The Role of Visceral Hypersensitivity in Irritable Bowel Syndrome: Pharmacological Targets and Novel Treatments
title_fullStr The Role of Visceral Hypersensitivity in Irritable Bowel Syndrome: Pharmacological Targets and Novel Treatments
title_full_unstemmed The Role of Visceral Hypersensitivity in Irritable Bowel Syndrome: Pharmacological Targets and Novel Treatments
title_short The Role of Visceral Hypersensitivity in Irritable Bowel Syndrome: Pharmacological Targets and Novel Treatments
title_sort role of visceral hypersensitivity in irritable bowel syndrome: pharmacological targets and novel treatments
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056566/
https://www.ncbi.nlm.nih.gov/pubmed/27431236
http://dx.doi.org/10.5056/jnm16001
work_keys_str_mv AT farzaeimohammadh theroleofvisceralhypersensitivityinirritablebowelsyndromepharmacologicaltargetsandnoveltreatments
AT bahramsoltaniroodabeh theroleofvisceralhypersensitivityinirritablebowelsyndromepharmacologicaltargetsandnoveltreatments
AT abdollahimohammad theroleofvisceralhypersensitivityinirritablebowelsyndromepharmacologicaltargetsandnoveltreatments
AT rahimiroja theroleofvisceralhypersensitivityinirritablebowelsyndromepharmacologicaltargetsandnoveltreatments
AT farzaeimohammadh roleofvisceralhypersensitivityinirritablebowelsyndromepharmacologicaltargetsandnoveltreatments
AT bahramsoltaniroodabeh roleofvisceralhypersensitivityinirritablebowelsyndromepharmacologicaltargetsandnoveltreatments
AT abdollahimohammad roleofvisceralhypersensitivityinirritablebowelsyndromepharmacologicaltargetsandnoveltreatments
AT rahimiroja roleofvisceralhypersensitivityinirritablebowelsyndromepharmacologicaltargetsandnoveltreatments