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Effect of Probiotics on Central Nervous System Functions in Animals and Humans: A Systematic Review
To systematically review the effects of probiotics on central nervous system function in animals and humans, to summarize effective interventions (species of probiotic, dose, duration), and to analyze the possibility of translating preclinical studies. Literature searches were conducted in Pubmed, M...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Neurogastroenterology and Motility
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056568/ https://www.ncbi.nlm.nih.gov/pubmed/27413138 http://dx.doi.org/10.5056/jnm16018 |
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author | Wang, Huiying Lee, In-Seon Braun, Christoph Enck, Paul |
author_facet | Wang, Huiying Lee, In-Seon Braun, Christoph Enck, Paul |
author_sort | Wang, Huiying |
collection | PubMed |
description | To systematically review the effects of probiotics on central nervous system function in animals and humans, to summarize effective interventions (species of probiotic, dose, duration), and to analyze the possibility of translating preclinical studies. Literature searches were conducted in Pubmed, Medline, Embase, and the Cochrane Library. Only randomized controlled trials were included. In total, 38 studies were included: 25 in animals and 15 in humans (2 studies were conducted in both). Most studies used Bifidobacterium (eg, B. longum, B. breve, and B. infantis) and Lactobacillus (eg, L. helveticus, and L. rhamnosus), with doses between 10(9) and 10(10) colony-forming units for 2 weeks in animals and 4 weeks in humans. These probiotics showed efficacy in improving psychiatric disorder-related behaviors including anxiety, depression, autism spectrum disorder (ASD), obsessive-compulsive disorder, and memory abilities, including spatial and non-spatial memory. Because many of the basic science studies showed some efficacy of probiotics on central nervous system function, this background may guide and promote further preclinical and clinical studies. Translating animal studies to human studies has obvious limitations but also suggests possibilities. Here, we provide several suggestions for the translation of animal studies. More experimental designs with both behavioral and neuroimaging measures in healthy volunteers and patients are needed in the future. |
format | Online Article Text |
id | pubmed-5056568 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Korean Society of Neurogastroenterology and Motility |
record_format | MEDLINE/PubMed |
spelling | pubmed-50565682016-10-11 Effect of Probiotics on Central Nervous System Functions in Animals and Humans: A Systematic Review Wang, Huiying Lee, In-Seon Braun, Christoph Enck, Paul J Neurogastroenterol Motil Review To systematically review the effects of probiotics on central nervous system function in animals and humans, to summarize effective interventions (species of probiotic, dose, duration), and to analyze the possibility of translating preclinical studies. Literature searches were conducted in Pubmed, Medline, Embase, and the Cochrane Library. Only randomized controlled trials were included. In total, 38 studies were included: 25 in animals and 15 in humans (2 studies were conducted in both). Most studies used Bifidobacterium (eg, B. longum, B. breve, and B. infantis) and Lactobacillus (eg, L. helveticus, and L. rhamnosus), with doses between 10(9) and 10(10) colony-forming units for 2 weeks in animals and 4 weeks in humans. These probiotics showed efficacy in improving psychiatric disorder-related behaviors including anxiety, depression, autism spectrum disorder (ASD), obsessive-compulsive disorder, and memory abilities, including spatial and non-spatial memory. Because many of the basic science studies showed some efficacy of probiotics on central nervous system function, this background may guide and promote further preclinical and clinical studies. Translating animal studies to human studies has obvious limitations but also suggests possibilities. Here, we provide several suggestions for the translation of animal studies. More experimental designs with both behavioral and neuroimaging measures in healthy volunteers and patients are needed in the future. Korean Society of Neurogastroenterology and Motility 2016-10 2016-10-01 /pmc/articles/PMC5056568/ /pubmed/27413138 http://dx.doi.org/10.5056/jnm16018 Text en © 2016 The Korean Society of Neurogastroenterology and Motility This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Wang, Huiying Lee, In-Seon Braun, Christoph Enck, Paul Effect of Probiotics on Central Nervous System Functions in Animals and Humans: A Systematic Review |
title | Effect of Probiotics on Central Nervous System Functions in Animals and Humans: A Systematic Review |
title_full | Effect of Probiotics on Central Nervous System Functions in Animals and Humans: A Systematic Review |
title_fullStr | Effect of Probiotics on Central Nervous System Functions in Animals and Humans: A Systematic Review |
title_full_unstemmed | Effect of Probiotics on Central Nervous System Functions in Animals and Humans: A Systematic Review |
title_short | Effect of Probiotics on Central Nervous System Functions in Animals and Humans: A Systematic Review |
title_sort | effect of probiotics on central nervous system functions in animals and humans: a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056568/ https://www.ncbi.nlm.nih.gov/pubmed/27413138 http://dx.doi.org/10.5056/jnm16018 |
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