The CCND1 870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma

A number of specific chromosomal abnormalities define the subgroups of multiple myeloma. In a meta-analysis of two genomewide association studies of multiple myeloma totaling 1,661 patients we investigated risk for developing a specific tumor karyotype. The t(11;14) (q13;q32) translocation in which...

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Detalles Bibliográficos
Autores principales: Weinhold, Niels, Johnson, David C, Chubb, Daniel, Chen, Bowang, Försti, Asta, Hosking, Fay J, Broderick, Peter, Ma, Yussanne P, Dobbins, Sara E, Hose, Dirk, Walker, Brian A, Davies, Faith E, Kaiser, Martin F, Li, Ni L, Gregory, Walter A, Jackson, Graham H, Witzens-Harig, Mathias, Neben, Kai, Hoffmann, Per, Nöthen, Markus M, Mühleisen, Thomas W, Eisele, Lewin, Ross, Fiona M, Jauch, Anna, Goldschmidt, Hartmut, Houlston, Richard S, Morgan, Gareth J, Hemminki, Kari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056630/
https://www.ncbi.nlm.nih.gov/pubmed/23502783
http://dx.doi.org/10.1038/ng.2583
Descripción
Sumario:A number of specific chromosomal abnormalities define the subgroups of multiple myeloma. In a meta-analysis of two genomewide association studies of multiple myeloma totaling 1,661 patients we investigated risk for developing a specific tumor karyotype. The t(11;14) (q13;q32) translocation in which CCDN1 is placed under the control of the immunoglobin heavy chain enhancer was strongly associated with the CCDN1 870G>A polymorphism (P =7.96 x10(-11)). These results provide for a model in which a constitutional genetic factor is associated with risk of a specific chromosomal translocation.

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