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The CCND1 870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma
A number of specific chromosomal abnormalities define the subgroups of multiple myeloma. In a meta-analysis of two genomewide association studies of multiple myeloma totaling 1,661 patients we investigated risk for developing a specific tumor karyotype. The t(11;14) (q13;q32) translocation in which...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056630/ https://www.ncbi.nlm.nih.gov/pubmed/23502783 http://dx.doi.org/10.1038/ng.2583 |
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| author | Weinhold, Niels Johnson, David C Chubb, Daniel Chen, Bowang Försti, Asta Hosking, Fay J Broderick, Peter Ma, Yussanne P Dobbins, Sara E Hose, Dirk Walker, Brian A Davies, Faith E Kaiser, Martin F Li, Ni L Gregory, Walter A Jackson, Graham H Witzens-Harig, Mathias Neben, Kai Hoffmann, Per Nöthen, Markus M Mühleisen, Thomas W Eisele, Lewin Ross, Fiona M Jauch, Anna Goldschmidt, Hartmut Houlston, Richard S Morgan, Gareth J Hemminki, Kari |
| author_facet | Weinhold, Niels Johnson, David C Chubb, Daniel Chen, Bowang Försti, Asta Hosking, Fay J Broderick, Peter Ma, Yussanne P Dobbins, Sara E Hose, Dirk Walker, Brian A Davies, Faith E Kaiser, Martin F Li, Ni L Gregory, Walter A Jackson, Graham H Witzens-Harig, Mathias Neben, Kai Hoffmann, Per Nöthen, Markus M Mühleisen, Thomas W Eisele, Lewin Ross, Fiona M Jauch, Anna Goldschmidt, Hartmut Houlston, Richard S Morgan, Gareth J Hemminki, Kari |
| author_sort | Weinhold, Niels |
| collection | PubMed |
| description | A number of specific chromosomal abnormalities define the subgroups of multiple myeloma. In a meta-analysis of two genomewide association studies of multiple myeloma totaling 1,661 patients we investigated risk for developing a specific tumor karyotype. The t(11;14) (q13;q32) translocation in which CCDN1 is placed under the control of the immunoglobin heavy chain enhancer was strongly associated with the CCDN1 870G>A polymorphism (P =7.96 x10(-11)). These results provide for a model in which a constitutional genetic factor is associated with risk of a specific chromosomal translocation. |
| format | Online Article Text |
| id | pubmed-5056630 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-50566302016-10-10 The CCND1 870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma Weinhold, Niels Johnson, David C Chubb, Daniel Chen, Bowang Försti, Asta Hosking, Fay J Broderick, Peter Ma, Yussanne P Dobbins, Sara E Hose, Dirk Walker, Brian A Davies, Faith E Kaiser, Martin F Li, Ni L Gregory, Walter A Jackson, Graham H Witzens-Harig, Mathias Neben, Kai Hoffmann, Per Nöthen, Markus M Mühleisen, Thomas W Eisele, Lewin Ross, Fiona M Jauch, Anna Goldschmidt, Hartmut Houlston, Richard S Morgan, Gareth J Hemminki, Kari Nat Genet Article A number of specific chromosomal abnormalities define the subgroups of multiple myeloma. In a meta-analysis of two genomewide association studies of multiple myeloma totaling 1,661 patients we investigated risk for developing a specific tumor karyotype. The t(11;14) (q13;q32) translocation in which CCDN1 is placed under the control of the immunoglobin heavy chain enhancer was strongly associated with the CCDN1 870G>A polymorphism (P =7.96 x10(-11)). These results provide for a model in which a constitutional genetic factor is associated with risk of a specific chromosomal translocation. 2013-03-17 2013-05 /pmc/articles/PMC5056630/ /pubmed/23502783 http://dx.doi.org/10.1038/ng.2583 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Weinhold, Niels Johnson, David C Chubb, Daniel Chen, Bowang Försti, Asta Hosking, Fay J Broderick, Peter Ma, Yussanne P Dobbins, Sara E Hose, Dirk Walker, Brian A Davies, Faith E Kaiser, Martin F Li, Ni L Gregory, Walter A Jackson, Graham H Witzens-Harig, Mathias Neben, Kai Hoffmann, Per Nöthen, Markus M Mühleisen, Thomas W Eisele, Lewin Ross, Fiona M Jauch, Anna Goldschmidt, Hartmut Houlston, Richard S Morgan, Gareth J Hemminki, Kari The CCND1 870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma |
| title | The CCND1 870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma |
| title_full | The CCND1 870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma |
| title_fullStr | The CCND1 870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma |
| title_full_unstemmed | The CCND1 870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma |
| title_short | The CCND1 870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma |
| title_sort | ccnd1 870g>a polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056630/ https://www.ncbi.nlm.nih.gov/pubmed/23502783 http://dx.doi.org/10.1038/ng.2583 |
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