Cargando…

The Architectural Chromatin Factor High Mobility Group A1 Enhances DNA Ligase IV Activity Influencing DNA Repair

The HMGA1 architectural transcription factor is an oncogene overexpressed in the vast majority of human cancers. HMGA1 is a highly connected node in the nuclear molecular network and the key aspect of HMGA1 involvement in cancer development is that HMGA1 simultaneously confers cells multiple oncogen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pellarin, Ilenia, Arnoldo, Laura, Costantini, Silvia, Pegoraro, Silvia, Ros, Gloria, Penzo, Carlotta, Triolo, Gianluca, Demarchi, Francesca, Sgarra, Riccardo, Vindigni, Alessandro, Manfioletti, Guidalberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056749/ https://www.ncbi.nlm.nih.gov/pubmed/27723831 http://dx.doi.org/10.1371/journal.pone.0164258

Ejemplares similares

HMGA1 positively regulates the microtubule-destabilizing protein stathmin promoting motility in TNBC cells and decreasing tumour sensitivity to paclitaxel
por: Sgubin, Michela, et al.
Publicado: (2022)

A novel mechanism of post-translational modulation of HMGA functions by the histone chaperone nucleophosmin
por: Arnoldo, Laura, et al.
Publicado: (2015)

HMGA1 Modulates Gene Transcription Sustaining a Tumor Signalling Pathway Acting on the Epigenetic Status of Triple-Negative Breast Cancer Cells
por: Penzo, Carlotta, et al.
Publicado: (2019)

A novel HMGA1-CCNE2-YAP axis regulates breast cancer aggressiveness
por: Pegoraro, Silvia, et al.
Publicado: (2015)

High Mobility Group A (HMGA): Chromatin Nodes Controlled by a Knotty miRNA Network
por: Sgarra, Riccardo, et al.
Publicado: (2020)

HMGA2 Antisense Long Non-coding RNAs as New Players in the Regulation of HMGA2 Expression and Pancreatic Cancer Promotion
por: Ros, Gloria, et al.
Publicado: (2020)

The High Mobility Group A1 (HMGA1) Chromatin Architectural Factor Modulates Nuclear Stiffness in Breast Cancer Cells
por: Senigagliesi, Beatrice, et al.
Publicado: (2019)

Proneural-Mesenchymal Transition: Phenotypic Plasticity to Acquire Multitherapy Resistance in Glioblastoma
por: Fedele, Monica, et al.
Publicado: (2019)

Translating Proteomic Into Functional Data: An High Mobility Group A1 (HMGA1) Proteomic Signature Has Prognostic Value in Breast Cancer
por: Maurizio, Elisa, et al.
Publicado: (2016)

Transcriptional Regulation of Glucose Metabolism: The Emerging Role of the HMGA1 Chromatin Factor
por: Chiefari, Eusebio, et al.
Publicado: (2018)

HMGA1 promotes metastatic processes in basal-like breast cancer regulating EMT and stemness
por: Pegoraro, Silvia, et al.
Publicado: (2013)

Identification and Characterization of New Molecular Partners for the Protein Arginine Methyltransferase 6 (PRMT6)
por: Lo Sardo, Alessandra, et al.
Publicado: (2013)

Correction: Identification and Characterization of New Molecular Partners for the Protein Arginine Methyltransferase 6 (PRMT6)
por: Lo Sardo, Alessandra, et al.
Publicado: (2013)

HMGA1 regulates the Plasminogen activation system in the secretome of breast cancer cells
por: Resmini, Giulia, et al.
Publicado: (2017)

HMGA1 Regulates the Expression of Replication-Dependent Histone Genes and Cell-Cycle in Breast Cancer Cells
por: Petrosino, Sara, et al.
Publicado: (2022)

HMGA1 promotes breast cancer angiogenesis supporting the stability, nuclear localization and transcriptional activity of FOXM1
por: Zanin, Rossella, et al.
Publicado: (2019)

The binding landscape of a partially-selective isopeptidase inhibitor with potent pro-death activity, based on the bis(arylidene)cyclohexanone scaffold
por: Ciotti, Sonia, et al.
Publicado: (2018)

Expression and Functional Characterization of Xhmg-at-hook Genes in Xenopus laevis
por: Macrì, Simone, et al.
Publicado: (2013)

The Epithelial–Mesenchymal Transition at the Crossroads between Metabolism and Tumor Progression
por: Fedele, Monica, et al.
Publicado: (2022)

DNA ligase IV syndrome; a review
por: Altmann, Thomas, et al.
Publicado: (2016)

Catalytically inactive DNA ligase IV promotes DNA repair in living cells
por: Goff, Noah J, et al.
Publicado: (2022)

Editorial: Hormone Receptors and Breast Cancer
por: Brunetti, Antonio, et al.
Publicado: (2019)

Epithelial–Mesenchymal Transition (EMT) 2021
por: Manfioletti, Guidalberto, et al.
Publicado: (2022)

Epithelial–Mesenchymal Transition (EMT)
por: Manfioletti, Guidalberto, et al.
Publicado: (2023)

NAD(+) is not utilized as a co-factor for DNA ligation by human DNA ligase IV
por: Zhao, Bailin, et al.
Publicado: (2020)

Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks
por: Liang, Li, et al.
Publicado: (2008)

Structural Insights into the Role of Domain Flexibility in Human DNA Ligase IV
por: Ochi, Takashi, et al.
Publicado: (2012)

Lithium promotes DNA stability and survival of ischemic retinal neurocytes by upregulating DNA ligase IV
por: Yang, Ying, et al.
Publicado: (2016)

Human DNA ligase IV is able to use NAD(+) as an alternative adenylation donor for DNA ends ligation
por: Chen, Shih-Hsun, et al.
Publicado: (2019)

Telomere dynamics and fusion of critically shortened telomeres in plants lacking DNA ligase IV
por: Heacock, Michelle L., et al.
Publicado: (2007)

Structure-Based Virtual Ligand Screening on the XRCC4/DNA Ligase IV Interface
por: Menchon, Grégory, et al.
Publicado: (2016)

Effects of DNA supercoiling on chromatin architecture
por: Corless, Samuel, et al.
Publicado: (2016)

Effects of DNA supercoiling on chromatin architecture
por: Corless, Samuel, et al.
Publicado: (2016)

Selection of Natural Compounds with HMGA-Interfering Activities and Cancer Cell Cytotoxicity
por: Mori, Mattia, et al.
Publicado: (2023)

Loss of DNA ligase IV prevents recognition of DNA by double-strand break repair proteins XRCC4 and XLF
por: Jayaram, Sumithra, et al.
Publicado: (2008)

The second AT-hook of the architectural transcription factor HMGA2 is determinant for nuclear localization and function
por: Cattaruzzi, Giacomo, et al.
Publicado: (2007)

Semaphorin-7A on Exosomes: A Promigratory Signal in the Glioma Microenvironment
por: Manini, Ivana, et al.
Publicado: (2019)

DNA knots occur in intracellular chromatin
por: Valdés, Antonio, et al.
Publicado: (2018)

Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: influence of terminal DNA sequence
por: Gu, Jiafeng, et al.
Publicado: (2007)

XLF-Cernunnos promotes DNA ligase IV–XRCC4 re-adenylation following ligation
por: Riballo, Enriqueta, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_2kisg4ip2ukqmubpskegejj7gs