Late sacral recurrence of rectal cancer treated by heavy ion radiotherapy: a case report

BACKGROUND: The need for surveillance of rare late recurrence of rectal cancer has not yet been established. Local control of unresectable skeletal metastasis is important for palliation of symptoms and support for systemic chemotherapy. CASE PRESENTATION: A Japanese man underwent preoperative pelvic irradiation (50.4 Gy/28 Fr) and low anterior resection at the age of 57 years. The pathological stage was II (T3N0M0). Nine years after the surgery, his carcinoembryonic antigen (CEA) level showed rapid elevation, although he had no symptoms. A computed tomography (CT) scan showed no evidence of recurrent lesions, but positron emission tomography (PET)-CT revealed abnormally high 2-[(18)F]-fluoro-2-deoxy-d-glucose accumulation in the sacrum. A CT-guided needle biopsy confirmed the diagnosis of metastatic adenocarcinoma from the previous rectal cancer. The sacral metastasis reached the S1/S2 level and was considered inoperable. Conventional radiotherapy was also excluded due to the previous history of pelvic irradiation. Finally, heavy ion radiotherapy with carbon ions was performed as radical local therapy (70.4 GyE/16 Fr). The patient did not consent to systemic chemotherapy immediately after the irradiation. Five months after radiotherapy, multiple lung metastases were noted on CT, followed by mediastinal and hilar lymph node metastases. Systemic chemotherapy was started 9 months after the irradiation. During this time, the patient experienced some degree of pain and loss in muscle strength of the left lower limb, and a second heavy ion irradiation (60.0 GyE/12 Fr) was performed 11 months after the previous irradiation. After that, the sacral lesion has been stable and his symptoms have not worsened. Two years after the heavy ion therapy, the patient steadily continues outpatient chemotherapy and his quality of life is relatively maintained. CONCLUSION: In case the risk of late recurrence is relatively high after rectal cancer surgery, clinicians should consider individual follow-up evaluations, including CEA measurements to allow for timely diagnosis and intervention. Heavy ion radiotherapy is effective for local control of sacral metastasis.