A Naturally Occurring Antibody Fragment Neutralizes Infectivity of Diverse Infectious Agents

A phosphorylated peptide, named K40H, derived from the constant region of IgMs was detected in human serum by liquid chromatography coupled to high-resolution mass spectrometry. Synthetic K40H proved to exert a potent in vitro activity against fungal pathogens, and to inhibit HIV-1 replication in vi...

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Detalles Bibliográficos
Autores principales: Polonelli, Luciano, Ciociola, Tecla, Elviri, Lisa, Zanello, Pier Paolo, Giovati, Laura, Arruda, Denise C., Muñoz, Julián E., Mortara, Renato A., Morace, Giulia, Borghi, Elisa, Galati, Serena, Marin, Oriano, Casoli, Claudio, Pilotti, Elisabetta, Ronzi, Paola, Travassos, Luiz R., Magliani, Walter, Conti, Stefania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057116/
https://www.ncbi.nlm.nih.gov/pubmed/27725769
http://dx.doi.org/10.1038/srep35018

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