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Oesophageal carcinoma: comparison of ex vivo high-resolution 3.0 T MR imaging with histopathological findings

High-resolution magnetic resonance (MR) images clearly depict the normal oesophageal wall as consisting of eight layers, which correlates well with histopathological findings. In 56 (91.8%) of 61 lesions, the depth of oesophageal wall invasion determined through MR imaging was consistent with histop...

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Autores principales: Wei, Yi, Wu, Sen, Shi, Dapeng, Dou, Shewei, Sun, Tingyi, Ning, Peigang, Zhao, Cuihua, Li, Ziyuan, Li, Xiaodong, Gao, Feifei, Li, Linlin, Zheng, Dandan, Zhu, Shaocheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057120/
https://www.ncbi.nlm.nih.gov/pubmed/27725771
http://dx.doi.org/10.1038/srep35109
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author Wei, Yi
Wu, Sen
Shi, Dapeng
Dou, Shewei
Sun, Tingyi
Ning, Peigang
Zhao, Cuihua
Li, Ziyuan
Li, Xiaodong
Gao, Feifei
Li, Linlin
Zheng, Dandan
Zhu, Shaocheng
author_facet Wei, Yi
Wu, Sen
Shi, Dapeng
Dou, Shewei
Sun, Tingyi
Ning, Peigang
Zhao, Cuihua
Li, Ziyuan
Li, Xiaodong
Gao, Feifei
Li, Linlin
Zheng, Dandan
Zhu, Shaocheng
author_sort Wei, Yi
collection PubMed
description High-resolution magnetic resonance (MR) images clearly depict the normal oesophageal wall as consisting of eight layers, which correlates well with histopathological findings. In 56 (91.8%) of 61 lesions, the depth of oesophageal wall invasion determined through MR imaging was consistent with histopathological staging (r = 0.975, P < 0.001). The sensitivity, specificity and accuracy for the mucosa were 71.4%, 98.1%, and 95.1%, respectively, and the corresponding values for the submucosa were 82.4%, 95.5%, and 91.8%; for the muscularis propria, the sensitivity, specificity and accuracy were 100%, 95.7%, and 96.7%, respectively, and for the adventitia, these values were 100%, 100%, and 100%. The Cohen k values for interobserver agreement were excellent: K = 0.839, P < 0.001 (observer 1 vs. observer 2); K = 0.908, P < 0.001 (observer 1 vs. observer 3); and K = 0.885, P < 0.01 (observer 2 vs. observer 3). High-resolution ex vivo MR images obtained with a 3.0 T scanner can be used to precisely evaluate oesophageal carcinoma invasion and provide good diagnostic sensitivity, specificity and accuracy.
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spelling pubmed-50571202016-10-24 Oesophageal carcinoma: comparison of ex vivo high-resolution 3.0 T MR imaging with histopathological findings Wei, Yi Wu, Sen Shi, Dapeng Dou, Shewei Sun, Tingyi Ning, Peigang Zhao, Cuihua Li, Ziyuan Li, Xiaodong Gao, Feifei Li, Linlin Zheng, Dandan Zhu, Shaocheng Sci Rep Article High-resolution magnetic resonance (MR) images clearly depict the normal oesophageal wall as consisting of eight layers, which correlates well with histopathological findings. In 56 (91.8%) of 61 lesions, the depth of oesophageal wall invasion determined through MR imaging was consistent with histopathological staging (r = 0.975, P < 0.001). The sensitivity, specificity and accuracy for the mucosa were 71.4%, 98.1%, and 95.1%, respectively, and the corresponding values for the submucosa were 82.4%, 95.5%, and 91.8%; for the muscularis propria, the sensitivity, specificity and accuracy were 100%, 95.7%, and 96.7%, respectively, and for the adventitia, these values were 100%, 100%, and 100%. The Cohen k values for interobserver agreement were excellent: K = 0.839, P < 0.001 (observer 1 vs. observer 2); K = 0.908, P < 0.001 (observer 1 vs. observer 3); and K = 0.885, P < 0.01 (observer 2 vs. observer 3). High-resolution ex vivo MR images obtained with a 3.0 T scanner can be used to precisely evaluate oesophageal carcinoma invasion and provide good diagnostic sensitivity, specificity and accuracy. Nature Publishing Group 2016-10-11 /pmc/articles/PMC5057120/ /pubmed/27725771 http://dx.doi.org/10.1038/srep35109 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Wei, Yi
Wu, Sen
Shi, Dapeng
Dou, Shewei
Sun, Tingyi
Ning, Peigang
Zhao, Cuihua
Li, Ziyuan
Li, Xiaodong
Gao, Feifei
Li, Linlin
Zheng, Dandan
Zhu, Shaocheng
Oesophageal carcinoma: comparison of ex vivo high-resolution 3.0 T MR imaging with histopathological findings
title Oesophageal carcinoma: comparison of ex vivo high-resolution 3.0 T MR imaging with histopathological findings
title_full Oesophageal carcinoma: comparison of ex vivo high-resolution 3.0 T MR imaging with histopathological findings
title_fullStr Oesophageal carcinoma: comparison of ex vivo high-resolution 3.0 T MR imaging with histopathological findings
title_full_unstemmed Oesophageal carcinoma: comparison of ex vivo high-resolution 3.0 T MR imaging with histopathological findings
title_short Oesophageal carcinoma: comparison of ex vivo high-resolution 3.0 T MR imaging with histopathological findings
title_sort oesophageal carcinoma: comparison of ex vivo high-resolution 3.0 t mr imaging with histopathological findings
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057120/
https://www.ncbi.nlm.nih.gov/pubmed/27725771
http://dx.doi.org/10.1038/srep35109
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