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Relationship between oxysterols and mild cognitive impairment in the elderly: a case–control study

BACKGROUND: To investigate the relationship between oxysterols and mild cognitive impairment (MCI) in a matched case–control study. METHODS: The plasma levels of four oxysterols, 27–hydroxycholesterol (27–OHC), 24S–hydroxycholesterol (24S–OHC), 7α–hydroxycholesterol (7α–OHC) and 7β–hydroxycholestero...

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Autores principales: Liu, Quanri, An, Yu, Yu, Huanling, Lu, Yanhui, Feng, Lingli, Wang, Chao, Xiao, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057217/
https://www.ncbi.nlm.nih.gov/pubmed/27724967
http://dx.doi.org/10.1186/s12944-016-0344-y
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author Liu, Quanri
An, Yu
Yu, Huanling
Lu, Yanhui
Feng, Lingli
Wang, Chao
Xiao, Rong
author_facet Liu, Quanri
An, Yu
Yu, Huanling
Lu, Yanhui
Feng, Lingli
Wang, Chao
Xiao, Rong
author_sort Liu, Quanri
collection PubMed
description BACKGROUND: To investigate the relationship between oxysterols and mild cognitive impairment (MCI) in a matched case–control study. METHODS: The plasma levels of four oxysterols, 27–hydroxycholesterol (27–OHC), 24S–hydroxycholesterol (24S–OHC), 7α–hydroxycholesterol (7α–OHC) and 7β–hydroxycholesterol (7β–OHC), were analyzed by High Performance Liquid Chromatography–Mass Spectrometry (HPLC–MS) and compared between 70 MCI patients and 140 matched controls with normal cognition. The odds ratio (OR) was calculated using logistic analyses to assess the association between oxysterols and MCI. RESULTS: Compared with controls with normal cognition, plasma level of 27–OHC was significantly higher in MCI patients. Logistic analyses suggested high plasma level of 27–OHC was significantly associated with MCI even after multivariate adjustment (OR = 2.86, 95 % CI: 1.52 ~ 5.37). CONCLUSIONS: Our findings suggested that the increased plasma level of 27-OHC was associated with MCI, suggesting high plasma levels of 27-OHC may pay an important role in the development of MCI.
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spelling pubmed-50572172016-10-20 Relationship between oxysterols and mild cognitive impairment in the elderly: a case–control study Liu, Quanri An, Yu Yu, Huanling Lu, Yanhui Feng, Lingli Wang, Chao Xiao, Rong Lipids Health Dis Research BACKGROUND: To investigate the relationship between oxysterols and mild cognitive impairment (MCI) in a matched case–control study. METHODS: The plasma levels of four oxysterols, 27–hydroxycholesterol (27–OHC), 24S–hydroxycholesterol (24S–OHC), 7α–hydroxycholesterol (7α–OHC) and 7β–hydroxycholesterol (7β–OHC), were analyzed by High Performance Liquid Chromatography–Mass Spectrometry (HPLC–MS) and compared between 70 MCI patients and 140 matched controls with normal cognition. The odds ratio (OR) was calculated using logistic analyses to assess the association between oxysterols and MCI. RESULTS: Compared with controls with normal cognition, plasma level of 27–OHC was significantly higher in MCI patients. Logistic analyses suggested high plasma level of 27–OHC was significantly associated with MCI even after multivariate adjustment (OR = 2.86, 95 % CI: 1.52 ~ 5.37). CONCLUSIONS: Our findings suggested that the increased plasma level of 27-OHC was associated with MCI, suggesting high plasma levels of 27-OHC may pay an important role in the development of MCI. BioMed Central 2016-10-10 /pmc/articles/PMC5057217/ /pubmed/27724967 http://dx.doi.org/10.1186/s12944-016-0344-y Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Liu, Quanri
An, Yu
Yu, Huanling
Lu, Yanhui
Feng, Lingli
Wang, Chao
Xiao, Rong
Relationship between oxysterols and mild cognitive impairment in the elderly: a case–control study
title Relationship between oxysterols and mild cognitive impairment in the elderly: a case–control study
title_full Relationship between oxysterols and mild cognitive impairment in the elderly: a case–control study
title_fullStr Relationship between oxysterols and mild cognitive impairment in the elderly: a case–control study
title_full_unstemmed Relationship between oxysterols and mild cognitive impairment in the elderly: a case–control study
title_short Relationship between oxysterols and mild cognitive impairment in the elderly: a case–control study
title_sort relationship between oxysterols and mild cognitive impairment in the elderly: a case–control study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057217/
https://www.ncbi.nlm.nih.gov/pubmed/27724967
http://dx.doi.org/10.1186/s12944-016-0344-y
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