Multiplexing of receptor occupancy measurements for pharmacodynamic biomarker assessment of biopharmaceuticals

BACKGROUND: Receptor occupancy (RO) assays measure drug target engagement, and are used as pharmacodynamic (PD) biomarkers. RO assays are commonly performed by flow cytometry and often require multiplexing for assessment of multiple PD biomarkers when specimen volumes are limited. We present multipl...

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Detalles Bibliográficos
Autores principales: Vainshtein, Inna, Schneider, Amy K., Sun, Bo, Schwickart, Martin, Roskos, Lorin K., Liang, Meina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057311/
https://www.ncbi.nlm.nih.gov/pubmed/26332491
http://dx.doi.org/10.1002/cyto.b.21319

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