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Impact of cytochrome P450 2C19 polymorphisms on the pharmacokinetics of tacrolimus when coadministered with voriconazole

This study evaluated the effects of cytochrome P450 (CYP) 2C19 polymorphisms on tacrolimus pharmacokinetics when coadministered with voriconazole. Eighteen healthy volunteers, including 6 individuals in each CYP2C19 genotype (extensive metabolizers [EMs], intermediate metabolizers [IMs], and poor me...

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Detalles Bibliográficos
Autores principales:	Imamura, Chiyo K., Furihata, Kenichi, Okamoto, Shinichiro, Tanigawara, Yusuke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2015
Materias:	Pharmacogenomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057355/ https://www.ncbi.nlm.nih.gov/pubmed/26239045 http://dx.doi.org/10.1002/jcph.605

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