Sinomenine activates astrocytic dopamine D2 receptors and alleviates neuroinflammatory injury via the CRYAB/STAT3 pathway after ischemic stroke in mice

BACKGROUND: Astrocyte-mediated neuroinflammation plays a critical role in ischemic stroke-induced secondary cerebral injury. Previous studies have suggested that the dopamine D2 receptor (DRD2) acts as a key target in regulating the neuroinflammatory response. However, the underlying molecular mecha...

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Detalles Bibliográficos
Autores principales: Qiu, Jing, Yan, Zhongjun, Tao, Kai, Li, Yansong, Li, Yuqian, Li, Jingchen, Dong, Yushu, Feng, Dayun, Chen, Huisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057372/
https://www.ncbi.nlm.nih.gov/pubmed/27724964
http://dx.doi.org/10.1186/s12974-016-0739-8

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