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Intracerebral Distribution of the Oncometabolite d-2-Hydroxyglutarate in Mice Bearing Mutant Isocitrate Dehydrogenase Brain Tumors: Implications for Tumorigenesis

The prevalence of mutant isocitrate dehydrogenase 1 (IDH1) brain tumors has generated significant efforts to understand the role of the mutated enzyme product d-2-hydroxyglutarate (D2HG), an oncometabolite, in tumorigenesis, as well as means to eliminate it. Glymphatic clearance was proposed as a pa...

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Detalles Bibliográficos
Autores principales:	Pickard, Amanda J., Sohn, Albert S. W., Bartenstein, Thomas F., He, Shan, Zhang, Yi, Gallo, James M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057413/ https://www.ncbi.nlm.nih.gov/pubmed/27781195 http://dx.doi.org/10.3389/fonc.2016.00211

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