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Circulating angiogenic factors in diabetes patients in a tertiary hospital in Ghana

BACKGROUND: Impaired angiogenesis is amongst the underlining mechanisms of organ damage in diabetes and hypertensive patients. In diabetes and hypertensive patients without proteinuria and overt CVDs, we studied the levels of angiogenic growth factors, angiopoietin (Ang)-1, Ang-2 and vascular endoth...

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Autores principales: Yeboah, Kwame, Kyei-Baafour, Eric, Antwi, Daniel A., Asare-Anane, Henry, Gyan, Ben, Amoah, Albert G. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057505/
https://www.ncbi.nlm.nih.gov/pubmed/27777900
http://dx.doi.org/10.1186/s40200-016-0267-1
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author Yeboah, Kwame
Kyei-Baafour, Eric
Antwi, Daniel A.
Asare-Anane, Henry
Gyan, Ben
Amoah, Albert G. B.
author_facet Yeboah, Kwame
Kyei-Baafour, Eric
Antwi, Daniel A.
Asare-Anane, Henry
Gyan, Ben
Amoah, Albert G. B.
author_sort Yeboah, Kwame
collection PubMed
description BACKGROUND: Impaired angiogenesis is amongst the underlining mechanisms of organ damage in diabetes and hypertensive patients. In diabetes and hypertensive patients without proteinuria and overt CVDs, we studied the levels of angiogenic growth factors, angiopoietin (Ang)-1, Ang-2 and vascular endothelial growth factor (VEGF), and the relationship between these angiogenic growth factors and renal function, measured as estimated glomerular filtration rate (eGFR). METHOD: In a case control design, 107 type 2 diabetes (T2DM) patients and 93 non-diabetes controls were recruited into the study. Levels of plasma glucose, lipids, creatinine and angiogenic growth factors; Ang-1, Ang-2 and VEGF measured from fasting blood samples. Estimated glomerular filtration rate (eGFR) was computed using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) algorithm and eGFR < 60 ml/min/1.73 m(2) was considered to be low. Multivariable logistic regression was used to assess the odds of change in angiogenic growth factors among patients with diabetes and hypertension, and patients with low eGFR, compared to those without these conditions. RESULTS: In a total of 200 participants with 49 % females and mean age of 54.1 ± 10.2 years, 22.7 % of T2DM patients and 13.3 % of non-diabetes participant had low eGFR. The levels of Ang-1 and Ang-2 were highest in hypertensive T2DM patients, followed by patients with either T2DM or hypertension alone, with the controls having the lowest levels. The odds of change in circulating Ang-2 levels increased in patients with both diabetes and hypertension [11.76 (7.97–16.63), p < 0.01] compared to patients with either diabetes [5.45 (3.31–9.71), p = 0.02] or hypertension [5.45 (3.31–9.71), p = 0.02] alone. Compared to those with normal eGFR, the odds of change in serum Ang-2 levels were increased in patients with low eGFR in both the crude [1.26 (1.08–2.110), p = 0.023] and adjusted [1.14 (1.03–2.34), p = 0.043] regression models. CONCLUSION: In our study population, having diabetes and hypertension increased the levels of Ang-1 and Ang-2. Also, low eGFR status was associated with increased levels of Ang-2 after adjustment for other risk factors.
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spelling pubmed-50575052016-10-24 Circulating angiogenic factors in diabetes patients in a tertiary hospital in Ghana Yeboah, Kwame Kyei-Baafour, Eric Antwi, Daniel A. Asare-Anane, Henry Gyan, Ben Amoah, Albert G. B. J Diabetes Metab Disord Research Article BACKGROUND: Impaired angiogenesis is amongst the underlining mechanisms of organ damage in diabetes and hypertensive patients. In diabetes and hypertensive patients without proteinuria and overt CVDs, we studied the levels of angiogenic growth factors, angiopoietin (Ang)-1, Ang-2 and vascular endothelial growth factor (VEGF), and the relationship between these angiogenic growth factors and renal function, measured as estimated glomerular filtration rate (eGFR). METHOD: In a case control design, 107 type 2 diabetes (T2DM) patients and 93 non-diabetes controls were recruited into the study. Levels of plasma glucose, lipids, creatinine and angiogenic growth factors; Ang-1, Ang-2 and VEGF measured from fasting blood samples. Estimated glomerular filtration rate (eGFR) was computed using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) algorithm and eGFR < 60 ml/min/1.73 m(2) was considered to be low. Multivariable logistic regression was used to assess the odds of change in angiogenic growth factors among patients with diabetes and hypertension, and patients with low eGFR, compared to those without these conditions. RESULTS: In a total of 200 participants with 49 % females and mean age of 54.1 ± 10.2 years, 22.7 % of T2DM patients and 13.3 % of non-diabetes participant had low eGFR. The levels of Ang-1 and Ang-2 were highest in hypertensive T2DM patients, followed by patients with either T2DM or hypertension alone, with the controls having the lowest levels. The odds of change in circulating Ang-2 levels increased in patients with both diabetes and hypertension [11.76 (7.97–16.63), p < 0.01] compared to patients with either diabetes [5.45 (3.31–9.71), p = 0.02] or hypertension [5.45 (3.31–9.71), p = 0.02] alone. Compared to those with normal eGFR, the odds of change in serum Ang-2 levels were increased in patients with low eGFR in both the crude [1.26 (1.08–2.110), p = 0.023] and adjusted [1.14 (1.03–2.34), p = 0.043] regression models. CONCLUSION: In our study population, having diabetes and hypertension increased the levels of Ang-1 and Ang-2. Also, low eGFR status was associated with increased levels of Ang-2 after adjustment for other risk factors. BioMed Central 2016-10-10 /pmc/articles/PMC5057505/ /pubmed/27777900 http://dx.doi.org/10.1186/s40200-016-0267-1 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Yeboah, Kwame
Kyei-Baafour, Eric
Antwi, Daniel A.
Asare-Anane, Henry
Gyan, Ben
Amoah, Albert G. B.
Circulating angiogenic factors in diabetes patients in a tertiary hospital in Ghana
title Circulating angiogenic factors in diabetes patients in a tertiary hospital in Ghana
title_full Circulating angiogenic factors in diabetes patients in a tertiary hospital in Ghana
title_fullStr Circulating angiogenic factors in diabetes patients in a tertiary hospital in Ghana
title_full_unstemmed Circulating angiogenic factors in diabetes patients in a tertiary hospital in Ghana
title_short Circulating angiogenic factors in diabetes patients in a tertiary hospital in Ghana
title_sort circulating angiogenic factors in diabetes patients in a tertiary hospital in ghana
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057505/
https://www.ncbi.nlm.nih.gov/pubmed/27777900
http://dx.doi.org/10.1186/s40200-016-0267-1
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