Cargando…
Circulating angiogenic factors in diabetes patients in a tertiary hospital in Ghana
BACKGROUND: Impaired angiogenesis is amongst the underlining mechanisms of organ damage in diabetes and hypertensive patients. In diabetes and hypertensive patients without proteinuria and overt CVDs, we studied the levels of angiogenic growth factors, angiopoietin (Ang)-1, Ang-2 and vascular endoth...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057505/ https://www.ncbi.nlm.nih.gov/pubmed/27777900 http://dx.doi.org/10.1186/s40200-016-0267-1 |
_version_ | 1782459084101910528 |
---|---|
author | Yeboah, Kwame Kyei-Baafour, Eric Antwi, Daniel A. Asare-Anane, Henry Gyan, Ben Amoah, Albert G. B. |
author_facet | Yeboah, Kwame Kyei-Baafour, Eric Antwi, Daniel A. Asare-Anane, Henry Gyan, Ben Amoah, Albert G. B. |
author_sort | Yeboah, Kwame |
collection | PubMed |
description | BACKGROUND: Impaired angiogenesis is amongst the underlining mechanisms of organ damage in diabetes and hypertensive patients. In diabetes and hypertensive patients without proteinuria and overt CVDs, we studied the levels of angiogenic growth factors, angiopoietin (Ang)-1, Ang-2 and vascular endothelial growth factor (VEGF), and the relationship between these angiogenic growth factors and renal function, measured as estimated glomerular filtration rate (eGFR). METHOD: In a case control design, 107 type 2 diabetes (T2DM) patients and 93 non-diabetes controls were recruited into the study. Levels of plasma glucose, lipids, creatinine and angiogenic growth factors; Ang-1, Ang-2 and VEGF measured from fasting blood samples. Estimated glomerular filtration rate (eGFR) was computed using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) algorithm and eGFR < 60 ml/min/1.73 m(2) was considered to be low. Multivariable logistic regression was used to assess the odds of change in angiogenic growth factors among patients with diabetes and hypertension, and patients with low eGFR, compared to those without these conditions. RESULTS: In a total of 200 participants with 49 % females and mean age of 54.1 ± 10.2 years, 22.7 % of T2DM patients and 13.3 % of non-diabetes participant had low eGFR. The levels of Ang-1 and Ang-2 were highest in hypertensive T2DM patients, followed by patients with either T2DM or hypertension alone, with the controls having the lowest levels. The odds of change in circulating Ang-2 levels increased in patients with both diabetes and hypertension [11.76 (7.97–16.63), p < 0.01] compared to patients with either diabetes [5.45 (3.31–9.71), p = 0.02] or hypertension [5.45 (3.31–9.71), p = 0.02] alone. Compared to those with normal eGFR, the odds of change in serum Ang-2 levels were increased in patients with low eGFR in both the crude [1.26 (1.08–2.110), p = 0.023] and adjusted [1.14 (1.03–2.34), p = 0.043] regression models. CONCLUSION: In our study population, having diabetes and hypertension increased the levels of Ang-1 and Ang-2. Also, low eGFR status was associated with increased levels of Ang-2 after adjustment for other risk factors. |
format | Online Article Text |
id | pubmed-5057505 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-50575052016-10-24 Circulating angiogenic factors in diabetes patients in a tertiary hospital in Ghana Yeboah, Kwame Kyei-Baafour, Eric Antwi, Daniel A. Asare-Anane, Henry Gyan, Ben Amoah, Albert G. B. J Diabetes Metab Disord Research Article BACKGROUND: Impaired angiogenesis is amongst the underlining mechanisms of organ damage in diabetes and hypertensive patients. In diabetes and hypertensive patients without proteinuria and overt CVDs, we studied the levels of angiogenic growth factors, angiopoietin (Ang)-1, Ang-2 and vascular endothelial growth factor (VEGF), and the relationship between these angiogenic growth factors and renal function, measured as estimated glomerular filtration rate (eGFR). METHOD: In a case control design, 107 type 2 diabetes (T2DM) patients and 93 non-diabetes controls were recruited into the study. Levels of plasma glucose, lipids, creatinine and angiogenic growth factors; Ang-1, Ang-2 and VEGF measured from fasting blood samples. Estimated glomerular filtration rate (eGFR) was computed using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) algorithm and eGFR < 60 ml/min/1.73 m(2) was considered to be low. Multivariable logistic regression was used to assess the odds of change in angiogenic growth factors among patients with diabetes and hypertension, and patients with low eGFR, compared to those without these conditions. RESULTS: In a total of 200 participants with 49 % females and mean age of 54.1 ± 10.2 years, 22.7 % of T2DM patients and 13.3 % of non-diabetes participant had low eGFR. The levels of Ang-1 and Ang-2 were highest in hypertensive T2DM patients, followed by patients with either T2DM or hypertension alone, with the controls having the lowest levels. The odds of change in circulating Ang-2 levels increased in patients with both diabetes and hypertension [11.76 (7.97–16.63), p < 0.01] compared to patients with either diabetes [5.45 (3.31–9.71), p = 0.02] or hypertension [5.45 (3.31–9.71), p = 0.02] alone. Compared to those with normal eGFR, the odds of change in serum Ang-2 levels were increased in patients with low eGFR in both the crude [1.26 (1.08–2.110), p = 0.023] and adjusted [1.14 (1.03–2.34), p = 0.043] regression models. CONCLUSION: In our study population, having diabetes and hypertension increased the levels of Ang-1 and Ang-2. Also, low eGFR status was associated with increased levels of Ang-2 after adjustment for other risk factors. BioMed Central 2016-10-10 /pmc/articles/PMC5057505/ /pubmed/27777900 http://dx.doi.org/10.1186/s40200-016-0267-1 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Yeboah, Kwame Kyei-Baafour, Eric Antwi, Daniel A. Asare-Anane, Henry Gyan, Ben Amoah, Albert G. B. Circulating angiogenic factors in diabetes patients in a tertiary hospital in Ghana |
title | Circulating angiogenic factors in diabetes patients in a tertiary hospital in Ghana |
title_full | Circulating angiogenic factors in diabetes patients in a tertiary hospital in Ghana |
title_fullStr | Circulating angiogenic factors in diabetes patients in a tertiary hospital in Ghana |
title_full_unstemmed | Circulating angiogenic factors in diabetes patients in a tertiary hospital in Ghana |
title_short | Circulating angiogenic factors in diabetes patients in a tertiary hospital in Ghana |
title_sort | circulating angiogenic factors in diabetes patients in a tertiary hospital in ghana |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057505/ https://www.ncbi.nlm.nih.gov/pubmed/27777900 http://dx.doi.org/10.1186/s40200-016-0267-1 |
work_keys_str_mv | AT yeboahkwame circulatingangiogenicfactorsindiabetespatientsinatertiaryhospitalinghana AT kyeibaafoureric circulatingangiogenicfactorsindiabetespatientsinatertiaryhospitalinghana AT antwidaniela circulatingangiogenicfactorsindiabetespatientsinatertiaryhospitalinghana AT asareananehenry circulatingangiogenicfactorsindiabetespatientsinatertiaryhospitalinghana AT gyanben circulatingangiogenicfactorsindiabetespatientsinatertiaryhospitalinghana AT amoahalbertgb circulatingangiogenicfactorsindiabetespatientsinatertiaryhospitalinghana |