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An improved reversibly dimerizing mutant of the FK506-binding protein FKBP

FK506-binding protein (FKBP) is a monomer that binds to FK506, rapamycin, and related ligands. The F36M substitution, in which Phe36 in the ligand-binding pocket is changed to Met, leads to formation of antiparallel FKBP dimers, which can be dissociated into monomers by ligand binding. This FKBP(M)...

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Detalles Bibliográficos
Autores principales:	Barrero, Juan J., Papanikou, Effrosyni, Casler, Jason C., Day, Kasey J., Glick, Benjamin S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2016
Materias:	Methods and Technologies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058350/ https://www.ncbi.nlm.nih.gov/pubmed/27738551 http://dx.doi.org/10.1080/21592799.2016.1204848

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