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Relationship between Plasma Triglyceride Level and Severity of Hypertriglyceridemic Pancreatitis
BACKGROUND: Hypertriglyceridemia is the third most common cause of acute pancreatitis, but whether the level of triglyceride (TG) is related to severity of pancreatitis is unclear. AIM: To evaluate the effect of TG level on the severity of hypertriglyceridemic pancreatitis (HTGP). DESIGN: Retrospect...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058492/ https://www.ncbi.nlm.nih.gov/pubmed/27727299 http://dx.doi.org/10.1371/journal.pone.0163984 |
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author | Wang, Sheng-Huei Chou, Yu-Ching Shangkuan, Wei-Chuan Wei, Kuang-Yu Pan, Yu-Han Lin, Hung-Che |
author_facet | Wang, Sheng-Huei Chou, Yu-Ching Shangkuan, Wei-Chuan Wei, Kuang-Yu Pan, Yu-Han Lin, Hung-Che |
author_sort | Wang, Sheng-Huei |
collection | PubMed |
description | BACKGROUND: Hypertriglyceridemia is the third most common cause of acute pancreatitis, but whether the level of triglyceride (TG) is related to severity of pancreatitis is unclear. AIM: To evaluate the effect of TG level on the severity of hypertriglyceridemic pancreatitis (HTGP). DESIGN: Retrospective cohort study. METHODS: We reviewed the records of 144 patients with HTGP from 1999 to 2013 at Tri-Service General Hospital. Patients with possible etiology of pancreatitis, such as gallstones, those consuming alcohol or drugs, or those with infections were excluded. The classification of severity of pancreatitis was based on the revised Atlanta classification. We allocated the patients into high-TG and low-TG groups based on the optimal cut-off value (2648 mg/dL), which was derived from the receiver operating characteristic (ROC) curve between TG level and severity of HTGP. We then compared the clinical characteristics, pancreatitis severity, and mortality rates of the groups. RESULTS: There were 66 patients in the low-TG group and 78 patients in the high-TG group. There was no significant difference in the age, sex ratio, body mass index, and comorbidity between the 2 groups. The high-TG group had significantly higher levels of glucose (P = 0.022), total cholesterol (P = 0.002), and blood urea nitrogen (P = 0.037), and lower levels of sodium (P = 0.003) and bicarbonate (P = 0.002) than the low-TG group. The incidences of local complication (P = 0.002) and severe and moderate form of pancreatitis (P = 0.004) were significantly higher in the high-TG group than in the low-TG group. The mortality rate was higher in the high-TG group than in the low-TG group (P = 0.07). CONCLUSIONS: Higher TG level in patients with HTGP may be associated with adverse prognosis, but randomized and prospective studies are needed in the future verify this relationship. |
format | Online Article Text |
id | pubmed-5058492 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-50584922016-10-27 Relationship between Plasma Triglyceride Level and Severity of Hypertriglyceridemic Pancreatitis Wang, Sheng-Huei Chou, Yu-Ching Shangkuan, Wei-Chuan Wei, Kuang-Yu Pan, Yu-Han Lin, Hung-Che PLoS One Research Article BACKGROUND: Hypertriglyceridemia is the third most common cause of acute pancreatitis, but whether the level of triglyceride (TG) is related to severity of pancreatitis is unclear. AIM: To evaluate the effect of TG level on the severity of hypertriglyceridemic pancreatitis (HTGP). DESIGN: Retrospective cohort study. METHODS: We reviewed the records of 144 patients with HTGP from 1999 to 2013 at Tri-Service General Hospital. Patients with possible etiology of pancreatitis, such as gallstones, those consuming alcohol or drugs, or those with infections were excluded. The classification of severity of pancreatitis was based on the revised Atlanta classification. We allocated the patients into high-TG and low-TG groups based on the optimal cut-off value (2648 mg/dL), which was derived from the receiver operating characteristic (ROC) curve between TG level and severity of HTGP. We then compared the clinical characteristics, pancreatitis severity, and mortality rates of the groups. RESULTS: There were 66 patients in the low-TG group and 78 patients in the high-TG group. There was no significant difference in the age, sex ratio, body mass index, and comorbidity between the 2 groups. The high-TG group had significantly higher levels of glucose (P = 0.022), total cholesterol (P = 0.002), and blood urea nitrogen (P = 0.037), and lower levels of sodium (P = 0.003) and bicarbonate (P = 0.002) than the low-TG group. The incidences of local complication (P = 0.002) and severe and moderate form of pancreatitis (P = 0.004) were significantly higher in the high-TG group than in the low-TG group. The mortality rate was higher in the high-TG group than in the low-TG group (P = 0.07). CONCLUSIONS: Higher TG level in patients with HTGP may be associated with adverse prognosis, but randomized and prospective studies are needed in the future verify this relationship. Public Library of Science 2016-10-11 /pmc/articles/PMC5058492/ /pubmed/27727299 http://dx.doi.org/10.1371/journal.pone.0163984 Text en © 2016 Wang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Wang, Sheng-Huei Chou, Yu-Ching Shangkuan, Wei-Chuan Wei, Kuang-Yu Pan, Yu-Han Lin, Hung-Che Relationship between Plasma Triglyceride Level and Severity of Hypertriglyceridemic Pancreatitis |
title | Relationship between Plasma Triglyceride Level and Severity of Hypertriglyceridemic Pancreatitis |
title_full | Relationship between Plasma Triglyceride Level and Severity of Hypertriglyceridemic Pancreatitis |
title_fullStr | Relationship between Plasma Triglyceride Level and Severity of Hypertriglyceridemic Pancreatitis |
title_full_unstemmed | Relationship between Plasma Triglyceride Level and Severity of Hypertriglyceridemic Pancreatitis |
title_short | Relationship between Plasma Triglyceride Level and Severity of Hypertriglyceridemic Pancreatitis |
title_sort | relationship between plasma triglyceride level and severity of hypertriglyceridemic pancreatitis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058492/ https://www.ncbi.nlm.nih.gov/pubmed/27727299 http://dx.doi.org/10.1371/journal.pone.0163984 |
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