Stability of Diazoxide in Extemporaneously Compounded Oral Suspensions

The objective of this study was to evaluate the stability of diazoxide in extemporaneously compounded oral suspensions. Oral suspensions of diazoxide 10 mg/mL were prepared from either bulk drug or capsules dispersed in either Oral Mix or Oral Mix Sugar Free. These suspensions were stored at 5°C and...

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Detalles Bibliográficos
Autores principales: Friciu, Mihaela, Zaraa, Sarra, Roullin, V. Gaëlle, Leclair, Grégoire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058506/
https://www.ncbi.nlm.nih.gov/pubmed/27727306
http://dx.doi.org/10.1371/journal.pone.0164577
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author Friciu, Mihaela
Zaraa, Sarra
Roullin, V. Gaëlle
Leclair, Grégoire
author_facet Friciu, Mihaela
Zaraa, Sarra
Roullin, V. Gaëlle
Leclair, Grégoire
author_sort Friciu, Mihaela
collection PubMed
description The objective of this study was to evaluate the stability of diazoxide in extemporaneously compounded oral suspensions. Oral suspensions of diazoxide 10 mg/mL were prepared from either bulk drug or capsules dispersed in either Oral Mix or Oral Mix Sugar Free. These suspensions were stored at 5°C and 25°C/60%RH in bottles and oral syringes for a total of 90 days. At predetermined time intervals, suspensions were inspected for homogeneity, color or odor change; the pH was measured and the concentration of diazoxide was evaluated by ultraviolet detection using a stability-indicating high pressure liquid chromatography method. All preparations were demonstrated to be chemically stable for at least 90 days.
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spelling pubmed-50585062016-10-27 Stability of Diazoxide in Extemporaneously Compounded Oral Suspensions Friciu, Mihaela Zaraa, Sarra Roullin, V. Gaëlle Leclair, Grégoire PLoS One Research Article The objective of this study was to evaluate the stability of diazoxide in extemporaneously compounded oral suspensions. Oral suspensions of diazoxide 10 mg/mL were prepared from either bulk drug or capsules dispersed in either Oral Mix or Oral Mix Sugar Free. These suspensions were stored at 5°C and 25°C/60%RH in bottles and oral syringes for a total of 90 days. At predetermined time intervals, suspensions were inspected for homogeneity, color or odor change; the pH was measured and the concentration of diazoxide was evaluated by ultraviolet detection using a stability-indicating high pressure liquid chromatography method. All preparations were demonstrated to be chemically stable for at least 90 days. Public Library of Science 2016-10-11 /pmc/articles/PMC5058506/ /pubmed/27727306 http://dx.doi.org/10.1371/journal.pone.0164577 Text en © 2016 Friciu et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Friciu, Mihaela
Zaraa, Sarra
Roullin, V. Gaëlle
Leclair, Grégoire
Stability of Diazoxide in Extemporaneously Compounded Oral Suspensions
title Stability of Diazoxide in Extemporaneously Compounded Oral Suspensions
title_full Stability of Diazoxide in Extemporaneously Compounded Oral Suspensions
title_fullStr Stability of Diazoxide in Extemporaneously Compounded Oral Suspensions
title_full_unstemmed Stability of Diazoxide in Extemporaneously Compounded Oral Suspensions
title_short Stability of Diazoxide in Extemporaneously Compounded Oral Suspensions
title_sort stability of diazoxide in extemporaneously compounded oral suspensions
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058506/
https://www.ncbi.nlm.nih.gov/pubmed/27727306
http://dx.doi.org/10.1371/journal.pone.0164577
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AT leclairgregoire stabilityofdiazoxideinextemporaneouslycompoundedoralsuspensions

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