Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats

Recently, it has been found that spontaneous mutation Lx (polydactyly-luxate syndrome) in the rat is determined by deletion of a conserved intronic sequence of the Plzf (Promyelocytic leukemia zinc finger protein) gene. In addition, Plzf is a prominent candidate gene for quantitative trait loci (QTL...

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Detalles Bibliográficos
Autores principales: Liška, František, Peterková, Renata, Peterka, Miroslav, Landa, Vladimír, Zídek, Václav, Mlejnek, Petr, Šilhavý, Jan, Šimáková, Miroslava, Křen, Vladimír, Starker, Colby G., Voytas, Daniel F., Izsvák, Zsuzsanna, Pravenec, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058558/
https://www.ncbi.nlm.nih.gov/pubmed/27727328
http://dx.doi.org/10.1371/journal.pone.0164206

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