Amelioration of Renal Inflammation, Endoplasmic Reticulum Stress and Apoptosis Underlies the Protective Effect of Low Dosage of Atorvastatin in Gentamicin-Induced Nephrotoxicity

Gentamicin is a commonly used aminoglycoside antibiotic. However, its therapeutic use is limited by its nephrotoxicity. The mechanisms of gentamicin-induced nephrotoxicity are principally from renal inflammation and oxidative stress. Since atorvastatin, 3-hydroxy-3-methylglutaryl coenzyme A reductas...

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Detalles Bibliográficos
Autores principales: Jaikumkao, Krit, Pongchaidecha, Anchalee, Thongnak, La-ongdao, Wanchai, Keerati, Arjinajarn, Phatchawan, Chatsudthipong, Varanuj, Chattipakorn, Nipon, Lungkaphin, Anusorn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058561/
https://www.ncbi.nlm.nih.gov/pubmed/27727327
http://dx.doi.org/10.1371/journal.pone.0164528

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