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Therapeutic Administration of a Monoclonal Anti-Il-1β Antibody Protects Against Experimental Melioidosis

BACKGROUND: Melioidosis, caused by the gram-negative bacterium Burkholderia pseudomallei, is a common cause of community-acquired sepsis in Southeast Asia and Northern Australia. The NLRP3 inflammasome and its downstream product interleukin-1 beta (IL-1β) have been proposed to play crucial roles in...

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Detalles Bibliográficos
Autores principales:	Weehuizen, Tassili A. F., Lankelma, Jacqueline M., De Jong, Hanna K., De Boer, Onno J., Roelofs, Joris J. T. H., Day, Nicholas P., Gram, Hermann, De Vos, Alex F., Wiersinga, W. Joost
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2016
Materias:	Basic Science Aspects
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058638/ https://www.ncbi.nlm.nih.gov/pubmed/27219859 http://dx.doi.org/10.1097/SHK.0000000000000625

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