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Effects of aging on the effectiveness of smoking cessation medication

BACKGROUND: Considering the pharmacokinetic and pharmacodynamic aspects of different medications, it is plausible that the age of a smoker could affect the half-life of these drugs. The aim of this study was to compare the effectiveness of smoking cessation drugs (nicotine replacement therapy, bupro...

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Autores principales: Scholz, Jaqueline, Santos, Paulo Caleb Junior Lima, Buzo, Carolina Giusti, Lopes, Neuza Helena Moreira, Abe, Tania Marie Ogawa, Gaya, Patricia Viviane, Pierri, Humberto, Amorim, Clarice, Pereira, Alexandre Costa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058661/
https://www.ncbi.nlm.nih.gov/pubmed/27166253
http://dx.doi.org/10.18632/oncotarget.9090
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author Scholz, Jaqueline
Santos, Paulo Caleb Junior Lima
Buzo, Carolina Giusti
Lopes, Neuza Helena Moreira
Abe, Tania Marie Ogawa
Gaya, Patricia Viviane
Pierri, Humberto
Amorim, Clarice
Pereira, Alexandre Costa
author_facet Scholz, Jaqueline
Santos, Paulo Caleb Junior Lima
Buzo, Carolina Giusti
Lopes, Neuza Helena Moreira
Abe, Tania Marie Ogawa
Gaya, Patricia Viviane
Pierri, Humberto
Amorim, Clarice
Pereira, Alexandre Costa
author_sort Scholz, Jaqueline
collection PubMed
description BACKGROUND: Considering the pharmacokinetic and pharmacodynamic aspects of different medications, it is plausible that the age of a smoker could affect the half-life of these drugs. The aim of this study was to compare the effectiveness of smoking cessation drugs (nicotine replacement therapy, bupropion, and varenicline) used either in isolation or in combination in adults under and over 60 years of age. METHODS: Data were collected from 940 Brazilian patients participating in a smoking cessation program. Participants were prescribed smoking cessation medication to be used for at least 12 weeks and were followed for 52 weeks. RESULTS: Cessation rates were significantly different among younger and older participants who were using nicotine replacement therapy (NRT) alone. Being over 60 years of age was significantly associated with increased cessation success among those who used NRT alone (OR 2.34, 95% CI: 1.36 to 4.04, p = 0.002). The effectiveness of varenicline and bupropion were not significantly different according to age groups. CONCLUSION: Using age as a predictor for tailoring smoking cessation drugs might potentially lead to a more individualized prescription of smoking cessation therapy. These results should be tested in randomized controlled trials.
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spelling pubmed-50586612016-10-15 Effects of aging on the effectiveness of smoking cessation medication Scholz, Jaqueline Santos, Paulo Caleb Junior Lima Buzo, Carolina Giusti Lopes, Neuza Helena Moreira Abe, Tania Marie Ogawa Gaya, Patricia Viviane Pierri, Humberto Amorim, Clarice Pereira, Alexandre Costa Oncotarget Research Paper: Gerotarget (Focus on Aging) BACKGROUND: Considering the pharmacokinetic and pharmacodynamic aspects of different medications, it is plausible that the age of a smoker could affect the half-life of these drugs. The aim of this study was to compare the effectiveness of smoking cessation drugs (nicotine replacement therapy, bupropion, and varenicline) used either in isolation or in combination in adults under and over 60 years of age. METHODS: Data were collected from 940 Brazilian patients participating in a smoking cessation program. Participants were prescribed smoking cessation medication to be used for at least 12 weeks and were followed for 52 weeks. RESULTS: Cessation rates were significantly different among younger and older participants who were using nicotine replacement therapy (NRT) alone. Being over 60 years of age was significantly associated with increased cessation success among those who used NRT alone (OR 2.34, 95% CI: 1.36 to 4.04, p = 0.002). The effectiveness of varenicline and bupropion were not significantly different according to age groups. CONCLUSION: Using age as a predictor for tailoring smoking cessation drugs might potentially lead to a more individualized prescription of smoking cessation therapy. These results should be tested in randomized controlled trials. Impact Journals LLC 2016-04-28 /pmc/articles/PMC5058661/ /pubmed/27166253 http://dx.doi.org/10.18632/oncotarget.9090 Text en Copyright: © 2016 Scholz et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper: Gerotarget (Focus on Aging)
Scholz, Jaqueline
Santos, Paulo Caleb Junior Lima
Buzo, Carolina Giusti
Lopes, Neuza Helena Moreira
Abe, Tania Marie Ogawa
Gaya, Patricia Viviane
Pierri, Humberto
Amorim, Clarice
Pereira, Alexandre Costa
Effects of aging on the effectiveness of smoking cessation medication
title Effects of aging on the effectiveness of smoking cessation medication
title_full Effects of aging on the effectiveness of smoking cessation medication
title_fullStr Effects of aging on the effectiveness of smoking cessation medication
title_full_unstemmed Effects of aging on the effectiveness of smoking cessation medication
title_short Effects of aging on the effectiveness of smoking cessation medication
title_sort effects of aging on the effectiveness of smoking cessation medication
topic Research Paper: Gerotarget (Focus on Aging)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058661/
https://www.ncbi.nlm.nih.gov/pubmed/27166253
http://dx.doi.org/10.18632/oncotarget.9090
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